Biology Forums - Study Force

What are angiogenic inhibitors and why are they being studied as possible treatments for
cancer?

I know the first part but I cannot relate it to cancer, anyhelp?

Look at the first sentence of the second paragraph.

This is there mechanism of action:

When a tumor stimulates the growth of new vessels, it is said to have undergone an 'angiogenic switch'. The principal stimulus for this angiogenic switch appears to be oxygen deprivation, although other stimuli such as inflammation, oncogenic mutations and mechanical stress may also play a role. The angiogenic switch leads to tumor expression of pro-angiogenic factors and increased tumor vascularization. Specifically, tumor cells release various pro-angiogenic paracrine factors (including angiogenin, vascular endothelial growth factor, fibroblast growth factor, and transforming growth factor-β. These stimulate endothelial cell proliferation, migration and invasion resulting in new vascular structures sprouting from nearby blood vessels. Cell adhesion molecules, such as integrins, are critical to the attachment and migration of endothelial cells to the extracellular matrix.