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Title: How does initiation of translation differ in eukaryotes and prokaryotes? Post by: typhoon01 on Feb 12, 2018 How does initiation of translation differ in eukaryotes and prokaryotes?
What will be an ideal response? Title: How does initiation of translation differ in eukaryotes and prokaryotes? Post by: agollub on Feb 12, 2018 Ans: In prokaryotes, the assembly of the 30S subunit occurs directly over the AUG via base pairing between the ribosome-binding site and the 16S rRNA. There is no complementarity between the sequences surrounding the AUG and the 18S rRNA of eukaryotes. Instead, initiation factors bind both the 5 methyl G cap and the poly(A) tail, and assemble with the 40S subunit at the 5 methyl G cap. The 40S subunit scans the mRNA from the 5 end until ribosomal proteins recognize the initiator region, or the ribosome-binding site. This sequence is NNNPuNNAUGG, where AUG is the initiator codon.
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