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Title: Use the following information to answer the next three questions. Post by: Aliya1 on May 15, 2018 #3. Bloom Syndrome
Bloom syndrome is a rare genetic disorder. It is characterized by a short stature and a long narrow face with prominent nose and ears. There is also an increased sensitivity to light. People who have the disorder often develop rashes on their face, forearms, and hands when they have been exposed to the sun. In addition, these people often suffer from chronic obstructive pulmonary disorder (COPD) and have a higher chance of developing cancer. bloom syndrome chromosomal location The cause of this genetic disorder is a mutation in the BLM gene located on chromosome 15. The immediate effect of this mutation is that there is a defect in the functioning of the DNA helicase enzyme. The location of this gene on the chromosome is indicated above. Below is a pedigree showing the genealogy of the BLM mutation in one family. What is the type of inheritance that causes this disorder? Justify your answer with two points. (2 marks) bloom syndrome mutation here are the images that go with this question. if you can please help me out with this i can answer the next 2 on my own. #4.What would be the effect of this mutation on DNA replication? What stage of the cell cycle would be most affected? #5.Note the location of the centromere in the diagram above. Knowing how the distance from the centromere affects the likelihood of crossing over, explain whether a Bloom syndrome trait has a high or low chance of crossing over. Title: Re: Use the following information to answer the next three questions. Post by: bio_man on May 15, 2018 Content hidden
Title: Re: Use the following information to answer the next three questions. Post by: Aliya1 on May 15, 2018 hi, thank you so much. can you please answer #3 for me? that's the one i am stuck on
#3.Below is a pedigree showing the genealogy of the BLM mutation in one family. What is the type of inheritance that causes this disorder? Justify your answer with two points. (2 marks) bloom syndrome mutation Title: Re: Use the following information to answer the next three questions. Post by: bio_man on May 15, 2018 Furthermore, according to the pedigree, it's likely a homozygous recessive trait (aa causes the effects we see). Also, it doesn't matter what your gender is, as it affects both males and females. I did ^^ Title: Re: Use the following information to answer the next three questions. Post by: Aliya1 on May 15, 2018 ohh sorry i thought that was all for #5. but thank you for letting me know :)
Title: Re: Use the following information to answer the next three questions. Post by: bio_man on May 15, 2018 Anyway I hope that's what they're looking for. I included my analysis in my initial post, see attachment.
Title: Re: Use the following information to answer the next three questions. Post by: Aliya1 on May 15, 2018 alright, i think that is what they're looking for i had a similar answer to you. thank you so much. have you got a chance to answer my other post regarding question #40 and #42?
Title: Re: Use the following information to answer the next three questions. Post by: bio_man on May 15, 2018 What's the link?
Title: Re: Use the following information to answer the next three questions. Post by: Aliya1 on May 15, 2018 hi, sorry for making you wait, i'm working on another assignment atm. but there is the link https://biology-forums.com/index.php?topic=1822768.msg4648943#msg4648943 i couldn't find the new topic where my questions were so this is the original post
i found it :) here's the link for questions 40 &42 https://biology-forums.com/index.php?topic=1823389.msg4647542#msg4647542 |