Title: Gene-Protein relationship Post by: ahmedmelmoselhy on Feb 12, 2019 Hello everyone, I am a Computer Science guy and I am interested in some Biology and following is my question.
Is it possible to know genes-proteins association? i.e for a certain protein, how can I know the set of genes contributed to produce that protein? Are there any online databases available for that purpose? Thanks. Title: Re: Gene-Protein relationship Post by: bio_man on Feb 12, 2019 Is it possible to know genes-proteins association? This is a major part of ongoing genetic research. Not all known genes that are part of the human genome have a known function, so many large pharmaceutical companies use their wealth to try to study how specific genes control aspects of human health. Also, be mindful that some genes work in tandem with others, so one particular gene may not have a known function on its own, unless it works together with a protein that's associated with a second or third gene. As a result, it is possible for these associations to be discovered, as many are already. To learn what's already been discovered, use the website database here: https://www.ncbi.nlm.nih.gov/gene Try writing down gene you're interested in Title: Re: Gene-Protein relationship Post by: ahmedmelmoselhy on Feb 12, 2019 Thanks for the informative answer.
I used NCBI to search for Gene: BRCA. Attached image part of the result What I understand is that BRCA1 contributes to producing those proteins, right? So, there is no complete source for all the known associations? e.g in a tabular format (genes Vs proteins) O.W should I build it one by one? Title: Re: Gene-Protein relationship Post by: bio_man on Feb 12, 2019 BRCA1 is the gene that encodes "Breast cancer type 1 susceptibility protein".
When it comes to searching, you have to keep in mind that other organisms also express the gene, so you have to be specific with the species you're researching by specifying it. Other versions found in other organisms are called orthologs. Perhaps use the source below for more information pertaining to humans only: https://www.uniprot.org/uniprot/P38398 Title: Re: Gene-Protein relationship Post by: ahmedmelmoselhy on Feb 13, 2019 Thanks a lot.
I've found a service on UniProt that allows me to search for genes and proteins for those genes, via "Retrieve/ID mapping" in UniProt. and the search result can be downloaded in many formats (including tabular format) which I found very useful, and I used it. Title: Re: Gene-Protein relationship Post by: bio_man on Feb 13, 2019 Thanks for the feedback ahmedmelmoselhy (https://biology-forums.com/index.php?action=profile;u=838961)
Title: Re: Gene-Protein relationship Post by: ahmedmelmoselhy on Feb 13, 2019 With pleasure Mr. @bio_man :)
Thanks for your support. |