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Title: Cancer - Vaccines. Post by: prashantakerkar on Jul 6, 2019 https://en.wikipedia.org/wiki/Cancer
Do you feel Vaccines can be created for Cancer disease in future? Cancer can affect any organ of Human Being. Are you optimistic? If Yes, Vaccines will be created for specific organ of the Human body or a Single vaccine ? Example : Cancer Vaccine for Mouth Cancer Vaccine for Lung Cancer Vaccine for Liver Cancer Vaccine for Pancreas Cancer Vaccine for Blood Cancer Vaccine for Brain and so on ... Thanks & Regards, Prashant S Akerkar Thanks. Great personalities like Steve Jobs, Nargis Dutt, Nazia Hassan, Manohar Parrikar and many more have died due to cancer disease. Thanks & Regards, Prashant S Akerkar Thanks. https://en.wikipedia.org/wiki/Gardasil https://en.wikipedia.org/wiki/Cervarix Similar to Gardasil & Cervarix cancer vaccines, Can other vaccines be manufactured for the specific Cancer organ ailment? Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Jul 6, 2019 Quote Do you feel Vaccines can be created for Cancer disease in future? I don't think vaccines - which activate one's adaptive immune system - can stop cancer cells from spreading. Cancer cells are not foreign cells, where foreign cells typically unknown cell receptors that can trigger an immune response. Cancer cells are technically mutated human cells whose DNA is messed up. In order for the immune system to initiate a response, it needs to "observe" foreign traits circulated in the blood or tissue. As mentioned, there are no cancer receptors. These receptor may also be present on normal cells, perhaps in different quantities and under developmental control. Take, for example the receptor encoded by the gene HER2; that receptor is just over expressed. It is also present and useful in normal cells. Similar to Gardasil & Cervarix cancer vaccines, Can other vaccines be manufactured for the specific Cancer organ ailment? Gardasil was designed to prevent the HPV species from infecting human cells. The reason why HPV can cause cancer is because of its pathogenicity. The viral DNA may integrate into the host genome from where the E6 and E7 genes are constitutively transcribed -- this is precisely how it may cause cancer because these genes could be inserted into genes that control the cell cycle! Please read https://www.ppdictionary.com/viruses/hpv.htm for more details. Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 6, 2019 Thanks. https://www.netdoctor.co.uk/medicines/cancer-drugs/ No cure once cancer reaches to the advanced III stage? Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Jul 6, 2019 There's no cure at all. Cancer is hindered by stopping cell growth, and as mentioned, since cancer cells don't have a special marker, all cells (healthy and unhealthy) need to stop replicating.
At later stages of cancers, it has spread everywhere, hence it becomes practically impossible. Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 6, 2019 Thanks. https://www.verywellhealth.com/celebrities-who-died-of-cancer-4020414 Famous people who died because of cancer. Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Jul 6, 2019 https://www.verywellhealth.com/celebrities-who-died-of-cancer-4020414 Sad. :( Thanks for sharing Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 6, 2019 Thanks.
https://en.wikipedia.org/wiki/Cancer_vaccine https://en.wikipedia.org/wiki/Tata_Memorial_Centre Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Jul 6, 2019 Thanks. https://en.wikipedia.org/wiki/Cancer_vaccine Thanks & Regards, Prashant S Akerkar This is not your traditional vaccine though. Take from Wikipedia: Tne approach to cancer vaccination is to separate proteins from cancer cells and immunize patients against those proteins as antigens, in the hope of stimulating the immune system to kill the cancer cells. Research on cancer vaccines is underway for treatment of breast, lung, colon, skin, kidney, prostate and other cancers.[5] Another approach is to generate an immune response in situ in the patient using oncolytic viruses. This approach was used in the drug talimogene laherparepvec, a version of herpes simplex virus engineered to selectively replicate in tumor tissue and to express the immune stimulatory protein GM-CSF. This enhances the anti-tumor immune response to tumor antigens released following viral lysis and provides a patient-specific vaccine.[6] Theoretically this could work as a final resort, but it's largely unproven. Still research is being conducted, and like I mentioned earlier, cancer cells go under the radar because they express nearly identical proteins to normal cells. Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 10, 2019 Thanks. https://en.wikipedia.org/wiki/Oncophage - Cancer Vaccine for Kidney. Thanks & Regards, Prashant S Akerkar Thanks. https://www.google.com/search?q=oncophage&prmd=mvni&source=lnms&tbm=isch&sa=X&ved=2ahUKEwj5iafV0qnjAhXTgeYKHdcUBFgQ_AUoBHoECAsQBA&biw=360&bih=592 Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: duddy on Jul 10, 2019 Thanks.https://en.wikipedia.org/wiki/Oncophage - Cancer Vaccine for Kidney.Thanks & Regards,Prashant S Akerkar Great read. I found an article that may interest you about this "oncophage". I know it's not a traditional vaccine, in the sense that vaccines PREVENT cancers, whereas this is a proactive approach to treatment after the fact, BUT it sounds promising @bio_man, what are your thoughts? Title: Re: Cancer - Vaccines. Post by: bio_man on Jul 10, 2019 Hey again everyone, this is worthy of a blog article!
Here's what I found. When these [oncophages; HSPPC-96] are re-administered to a patient following surgery or biopsy of the tumour, the antigenic tumour peptides are expressed on the surface of potent antigen-presenting cells of the immune system, such as macrophages and dendritic cells. This stimulates a much more powerful anti-tumour immune response than that generated by expression of the same antigens by the tumour cell. Thus, Antigenics autologous HSP technology is attractive because it is highly specific for individual patients and circumvents the need for identification of specific antigens for individual cancers (i.e. it does not require definition of the antigenic epitopes on cancer cells) and it overcomes the immune tolerance associated with various tumours. Oncophage is manufactured in a 10-hour process from surgically resected autologous tumour. A minimum of 1-3g of tumour tissue is required to produce enough Oncophage for a course of treatment. The major limiting factor for producing Oncophage from a particular cancer is the ability to purify HSP from that cancer. From clinical studies to date, Antigenics has been able to produce HSP from 100, 98, 90, 71 and 30% of colorectal carcinoma, renal cell carcinoma, melanoma, gastric cancer and pancreatic cancer tumours, respectively. > Sourced below Very promising stuff, but why haven't they continued with the research? I'd think it has to do with its success rate. For example, on Wikipedia, it states: "A first phase I clinical trial in glioma extended median survival of the group of patients, which was diagnosed with multiple recurrencies of glioma, to over 10 months." Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 10, 2019 Thank you. Thanks for the articles on Oncophage Vaccine for Kidney cancer. Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: duddy on Jul 10, 2019 np 👍
Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 10, 2019 Thanks.
https://www.ncbi.nlm.nih.gov/pubmed/11909004 Oncophage Vaccine or its variants can have a potential for Pancreatic & Colorectal Cancer cure as per the article? Thanks & Regards, Prashant S Akerkar Thanks. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncophage Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Jul 11, 2019 This idea is the same for all cancer types. Except according to the article, the failure rate for pancreatic cancer is higher because pancreatic cells (as per the article) have high concentration of proteases in that tissue type. Proteases are enzymes that breakdown proteins; hence, it's likely digest the substance before it can be processed by the adaptive immune system cells.
Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 15, 2019 https://medicalxpress.com/news/2010-10-scientists-cancer-purely-man-made.html
Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: duddy on Jul 15, 2019 https://medicalxpress.com/news/2010-10-scientists-cancer-purely-man-made.html Thanks & Regards, Prashant S Akerkar I can't seem to fully agree here because there's not one instance of proof that shows a normal cell becoming cancerous in the presence of a chemical. For example, we know that people who smoke cigarettes have a higher likelihood of developing lung disease, but they've never actually shown the toxins in the smoke making a cell "cancerous" in real-time. In fact, they can't even isolate a chemical within the smoke that'll cause it. A statement like that is very easy to make, but very hard to prove clinically. You can get away with making statements like that by looking at historical database, but then you can say that the data is incomplete, so how's it valid? The article mentions: Although this statistical construct is true, individuals in ancient Egypt and Greece did live long enough to develop such diseases as atherosclerosis, Paget's disease of bone, and osteoporosis, and, in modern populations, bone tumours primarily affect the young. Which suggests that people back then didn't live long enough for cancer to be seen widely in the population. Also, genetics plays a major role in cancer too. Women who've inherited the mutated alleles of the brca1 gene are more likely to develop onset breast cancer than women who don't -- that has little to do with the environment. Title: Re: Cancer - Vaccines. Post by: Fattbatts on Jul 15, 2019 Cancer has many causative risk factors. Many of them are avoidable but human population is just not avoiding them in spite of in depth knowledge. Simple example is smoking,our life style and to add fast pace industrialisation increasing chemical carcinogens, food adulterations, etc.
I will put ,cancer is not man made disease as it has been there since ages but human population has knowingly or unknowingly added to continued occurrence. Many factors are beyond our control. Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 20, 2019 Thanks.
https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/stem-cell-transplant.html Stem cell transplants can help in curing certain types of cancer such as leukaemia ? Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Jul 20, 2019 Yes, specifically acute myeloid leukemia (AML), through bone marrow transplants (also known as blood stem cell transplants) . Healthy cells are obtained from a donor first (I remember it's extracted from the pelvic bone because it's spongy). Oftentimes the donor is a family member, though unrelated donor or umbilical cord blood (if stored from birth, for example) also works.
However, before the transplant, the recipient needs to get chemotherapy first - with or without radiation - to kill the unhealthy cells. Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Jul 22, 2019 Thank you.
https://www.linkedin.com/in/sanket-awate-47081080 This is a great profile. Post Doctoral fellow - Cancer biologist. Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Jul 22, 2019 Great resume 👍👍
Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Aug 26, 2019 Thanks.
https://www.google.com/search?q=cancer+disease&tbm=isch&ved=2ahUKEwiInvaeiqDkAhXA0nMBHSdABLkQ2-cCegQIABAC&oq=cancer+disease&gs_l=mobile-gws-wiz-img.12..0l5.11484.15843..17094...0.0..0.185.1474.0j10......0....1.........41j0i67.gKyEGlZD1Iw&ei=IpNjXYiFMMClz7sPp4CRyAs&bih=592&biw=360&prmd=inbv I am highly optimistic that one day Cancer Vaccines will be available for all Human Being Organs. Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Aug 26, 2019 Thanks. https://www.google.com/search?q=cancer+disease&tbm=isch&ved=2ahUKEwiInvaeiqDkAhXA0nMBHSdABLkQ2-cCegQIABAC&oq=cancer+disease&gs_l=mobile-gws-wiz-img.12..0l5.11484.15843..17094...0.0..0.185.1474.0j10......0....1.........41j0i67.gKyEGlZD1Iw&ei=IpNjXYiFMMClz7sPp4CRyAs&bih=592&biw=360&prmd=inbv I am highly optimistic that one day Cancer Vaccines will be available for all Human Being Organs. Thanks & Regards, Prashant S Akerkar Sadly, I don't see that ever happening. The science behind prevention through vaccines doesn't apply to cancer because cancer is not something you can catch in the air, or transferable from person-to-person, or particularly caused by a pathogen. However, if it were caused by a pathogen, such as a virus of bacteria, and we knew the specific part of that of that organism leads to cancer (such a protein within it), only then could we make a vaccine. For instance, we know HPV (https://ppdictionary.com/viruses/hpv.htm) causes cervical cancer when left untreated, so we've made vaccines that are against HPV. Notice here we didn't make a cancer vaccine, but a cancer that's opposing the pathogen, which potentially can lead to the disease. The issue is that very few pathogens are directly linked to cancer. In the case of cigarette smokers, there's a correlation between smoking and lung cancer. What vaccine could we make here? The smoke is poisonous no matter what protection you give your body. Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Apr 4, 2020 Thanks.
Prof Ian Frazer - HPV vaccine against Cervical cancer. https://www.google.com/search?sxsrf=ALeKk00XUBDAYvBjQbANFmTIay3Hstcs9A%3A1586057513782&source=hp&ei=KVGJXqiyLauY4-EPwvq-oA4&q=prof+ian+frazer&gs_ssp=eJzj4tTP1TdIMiqwMDNg9OIvKMpPU8hMzFNIK0qsSi0CAHM4CMQ&oq=Prof+Ian+Fra&gs_lcp=ChFtb2JpbGUtZ3dzLXdpei1ocBABGAAyBQguEJMCMgIIADICCAAyAggAMgIIADIFCAAQzQIyBQgAEM0CMgUIIRCgAToHCCMQ6gIQJzoHCC4Q6gIQJzoECCMQJzoFCAAQkQI6BQgAEIMBOgUILhCDAToECC4QJzoFCC4QkQI6AgguULsRWM5SYIRmaAJwAHgAgAG8BYgBnBeSAQswLjkuMi4xLjYtMZgBAKABAbABCA&sclient=mobile-gws-wiz-hp Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Apr 5, 2020 Oncophage Vaccine or its variants can have a potential for Pancreatic & Colorectal Cancer cure as per the article? That's a different type of cure unrelated to the pathophysiology of the coronavirus. Phages are viruses that infect bacteria; the idea here is to turn-off or pause the genes that have been corrupt due to cancer using genes engineered into the phage, thereby acting as a mail carrier. When the phage enters the bloodstream, it would target pancreatic cells and inject its new DNA into the cells of that organ. The genes would be incorporated into the host DNA, and in turn, produce proteins that inhibit the spread. This is a good example of gene modification and genetic engineering. Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Apr 6, 2020 Thanks. Attached Prostrate cancer vaccine research by Jenner institute. #ChAdOx1 As we see, Jenner institute are currently working on COVID-19 vaccine development. Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Apr 6, 2020 From what I've read, the prostate cancer vaccine works by getting the immune system to recognize and attack prostate cancer cells. The vaccine targets a particular protein called prostatic acid phosphatase (PAP) that is produced at high levels by most prostate cancers. To make the vaccine, doctors collect a certain type of white blood cell from the man’s own blood, and then treat these immune cells with a chemical that allows them to recognize and mount an immune response against PAP when injected back into the man’s bloodstream in the form of the vaccine.
Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Oct 10, 2021 Thanks.
https://www.google.com/search?q=neuroendocrine+tumor&oq=neur&aqs=chrome.1.69i57j69i59j0i273i433j69i61l2.4196j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8 Are you optimistic in manufacturing vaccine for neuroendocrine cancer? Thanks & Regards, Prashant S Akerkar Thanks. Nice article on Cancer vaccines. https://www.verywellhealth.com/cancer-vaccines-5094151 Thanks & Regards, Prashant S Akerkar Title: Re: Cancer - Vaccines. Post by: bio_man on Oct 10, 2021 Content hidden
Title: Re: Cancer - Vaccines. Post by: prashantakerkar on Mar 30, 2022 Thanks.
https://www.google.com/search?q=Cancer+vaccines&source=hp&ei=XdtDYp74Be-Nr7wP3NyTuAs&oq=Cancer+vaccines&gs_lcp=ChFtb2JpbGUtZ3dzLXdpei1ocBADMgUIABCABDIFCAAQgAQyBQgAEIAEMgUIABCABDIFCAAQgAQyCAgAEIAEEMkDMgUIABCABDIFCAAQgAQ6CAgAEIAEELEDOgsIABCABBCxAxCDAToICC4QsQMQgwE6EQguEIAEELEDEIMBEMcBENEDOgsILhCABBCxAxDUAjoRCC4QgAQQsQMQgwEQxwEQowI6CwguEIAEEMcBEK8BOgUILhCABFCxDFjbNGDIOGgBcAB4AIABzQGIAccSkgEGMC4xMy4ymAEAoAEBsAEA&sclient=mobile-gws-wiz-hp Thanks & Regards, Prashant S Akerkar |