Biology Forums - Study Force

https://www.google.com/search?q=antiviral+agents+for+respiratory+diseases&tbm=isch&ved=2ahUKEwjvjMTWlq3oAhWT5TgGHQu2Ag8Q2-cCegQIABAC&oq=antiviral+agents+for+respiratory+diseases&gs_l=mobile-gws-wiz-img.12...0.0..375196...0.0..0.0.0.......0.iqDUGjxJ5FI&ei=e-B2Xq_jEJPL4-EPi-yKeA&bih=592&biw=360&prmd=insv

https://www.google.com/search?q=antiviral+agents+for+respiratory+diseases&tbm=isch&chips=q:antiviral+agents+for+respiratory+diseases,online_chips:viral+pneumonia&prmd=insv&hl=en&ved=2ahUKEwjaleX9pq3oAhXzD7cAHW7ZBkwQ4lYoAHoECAEQCw&biw=360&bih=592

This could be a good reference for manufacturing vaccines & cure /treatment drugs for COVID-19.

Thanks & Regards,
Prashant S Akerkar

Thanks.

Attached image.

Thanks & Regards,
Prashant S Akerkar

The same idea applies. Antiviral drugs work in two major ways, either they

1) they block the entry of the virus into the cell, or
2) prevent the drug from replicating once it has entered into the cell.

All those outlined in the link fall into one of these categories, generally.

Thank you.

https://www.genengnews.com/news/coronavirus-treatment-could-lie-in-existing-drugs/

Thanks & Regards,
Prashant S Akerkar

Thanks.

https://www.genengnews.com/category/virology/coronavirus/

Thanks & Regards,
Prashant S Akerkar

Thanks.

https://www.medicalnewstoday.com/articles/coronavirus-existing-drugs-could-be-repurposed-to-treat-infection

Thanks & Regards,
Prashant S Akerkar

The general idea behind modern antiviral drug design is to identify viral proteins, or parts of proteins, that can be disabled. These "targets" should generally be as unlike any proteins or parts of proteins in humans as possible, to reduce the likelihood of side effects. The targets should also be common across many strains of a virus, or even among different species of virus in the same family, so a single drug will have broad effectiveness. For example, a researcher might target a critical enzyme synthesized by the virus, but not the patient, that is common across strains, and see what can be done to interfere with its operation.

Once targets are identified, candidate drugs can be selected, either from drugs already known to have appropriate effects, or by actually designing the candidate at the molecular level with a computer-aided design program.

Thanks.

Reference : Pangolin

https://www.nytimes.com/2020/02/10/science/pangolin-coronavirus.html

Thanks & Regards,
Prashant S Akerkar

Thanks.

The Host carrier tracing of the COVID - 19 will be the key in manufacturing vaccine for the same.

i.e. Pangolin, Bats ...

Do you agree?

Thanks & Regards,
Prashant S Akerkar

When I look at this animal, I don't see it as something I'd be interested in eating, and definitely not by choice. I'm not even curious about how it tastes, at the end of the day it's probably no different than beef or pork. Not sure what the fascination is of the Chinese culture eating these animals, wish someone could explain it to me.

No, not true. We, too, are hosts.

Thanks.

Vaccines updates news for COVID-19.

Dr Anthony Fauci

https://m.facebook.com/story.php?story_fbid=624068521715499&id=5550296508

Prof Ian Fraser

https://m.facebook.com/story.php?story_fbid=3208264875887994&id=107637365950776

Thanks & Regards,
Prashant S Akerkar

Conceptually it isn't difficult, conceptually. In other words, theoretically the science behind it is simple if you understand the basics of biology. However, we don't know the impact it will have on the recipient 3 months, 6 months, a year from now.


Thanks for sharing, interesting take by a world-renowned medical doctor

Thanks.

https://news.utexas.edu/2020/02/19/breakthrough-in-coronavirus-research-results-in-new-map-to-support-vaccine-design/

Thanks & Regards,
Prashant S Akerkar

Thanks.

https://m.box.com/shared_item/https%3A%2F%2Futexas.box.com%2Fs%2Fwbmj6r6z2wppn4ue7b1qgkjsjx2nxubr/view/619416289158

Thanks & Regards,
Prashant S Akerkar

Thanks.

Jason Mclellan Labs research on COVID-19 vaccine.

Thanks & Regards,
Prashant S Akerkar

Thanks.

Jason Labs are doing good work in designing & developing a COVID-19 vaccine.

References:

Comparing Genome sequences.

https://en.wikipedia.org/wiki/Comparative_genomics

https://www.google.com/search?q=comparing+genome+sequences&oq=comparing+genom&aqs=chrome.2.69i57j0l3.7050j1j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8

What's your opinion?

Thanks & Regards,
Prashant S Akerkar

Thanks.

Attached Reference.

Thanks & Regards,
Prashant S Akerkar

Thanks.

Modern drugs & vaccine design & development abstract using comparative genomics.

Thanks & Regards,
Prashant S Akerkar

Comparative genomics is used to compare genomic features between different or similar organisms. It allows us to understand how the virus' genome changes from one recipient to the other, helping to predict how quickly it mutates and which parts of the species is most prone to mutation. We've already used it to identify the possible origins of the virus, where the one harvested from humans and that found natively in bats share a 99% similar genome. We will be using it forward to make future vaccines if the spread were to continue, much the same way the flu mutates every year.

Thanks for sharing these excellent resources, this document was particular informative: annurev-virology-110615-042301.pdf

Thanks.

https://covid19vaccinetrial.co.uk/home

https://www.facebook.com/jennerinstitute/

Are you optimistic regarding this vaccine research?

Thanks & Regards,
Prashant S Akerkar

Thanks.

https://www.google.com/search?q=jenner+institute+oxford&oq=&aqs=chrome.0.35i39l4j69i177.-1j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8

https://en.wikipedia.org/wiki/Edward_Jenner_Institute_for_Vaccine_Research

https://www.ndm.ox.ac.uk/the-jenner-institute

Thanks & Regards,
Prashant S Akerkar

Thanks.

ChAdOx1

https://www.google.com/search?q=ChAdOx1&oq=ChAdOx1+&aqs=chrome..69i57.18441j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8

This looks a promising vaccine.

What's your opinion?

Thanks & Regards,
Prashant S Akerkar

Thanks.

https://www.google.com/search?tbm=isch&sxsrf=ALeKk013U4e9jef0yGYCdUyRWpIDKa31Hg%3A1585849685018&source=hp&ei=VCWGXo-rPJWvyAPUyYlw&q=ChAdOx1

Your opinion regarding ChAdOx1.

This looks promising?

Thanks & Regards,
Prashant S Akerkar

Not by this organization. I don't think they have the best leadership.

ChAdOx1 is a vaccine adenovirus vector that could be used to deliver vaccine antigens where strong cellular immune responses are required. I don't see a problem using this, and it looks like they're moving forward with it:

The ChAdOx1 MERS vaccine consists of the replication-deficient simian adenovirus vector ChAdOx1, containing the MERS Spike protein antigen.

https://ichgcp.net/clinical-trials-registry/NCT03399578

Thanks.

https://en.wikipedia.org/wiki/Sarah_Gilbert_(scientist)

https://www.theguardian.com/society/2020/mar/19/uk-drive-develop-coronavirus-vaccine-science

https://en.wikipedia.org/wiki/Adenoviridae


Thanks & Regards,
Prashant S Akerkar

I just don't think her team will rise to the top on this one

Thanks.

https://www.jenner.ac.uk/

We should be optimistic. Isn' it?

Thanks & Regards,
Prashant S Akerkar

Of course, but it's more important to be realistic with the timeline. As per their website:


So while everyone is working diligently towards a common goal, to ensure safety and health risk management issues are properly addressed, time needs to be taken to do things right.

https://www.linkedin.com/mwlite/company/curevac

https://www.google.com/search?q=franz+werner+haas&oq=&aqs=chrome.1.35i39l3j46j69i177.-1j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8

https://www.google.com/search?client=ms-android-lava&sxsrf=ALeKk03tz2HNNpAbkihB9gcpk0WvKNlSmg%3A1586069020398&ei=HH6JXvHEF4vC3LUPv_if8AM&q=franz+werner+haas+on+COVID-19+vaccine+development&oq=franz+werner+haas+on+COVID-19+vaccine+development&gs_lcp=ChNtb2JpbGUtZ3dzLXdpei1zZXJwEAw6BggAEBYQHjoFCCEQoAFQ0hJYuoEBYJWJAWgAcAB4BIAB4wWIAYQ8kgEOMC4xNy4xLjAuMi4zLjOYAQCgAQE&sclient=mobile-gws-wiz-serp

https://www.curevac.com/contact-us#

Curevac GmbH pharma co is also working on COVID-19 vaccine.

We can get the latest updates from them regarding the COVID-19 vaccine development stage by sending emails?



Thanks & Regards,
Prashant S Akerkar

Thanks.

Latest updates regarding COVID-19 vaccine development.

info@curevac.com
communications@curevac.com

Thanks & Regards,
Prashant S Akerkar

For each milestone, they should publish an article on their findings. You could email them, but I'd wait for a major breakthrough.


You're most likely to get an auto response, but I'm curious to see how they'd respond. I'd guess they only respond to journals or prominents members of health departments around the world.

Give it a try, report back to us!

Thanks.

Curevac has published news in New York Times on 4th April regarding COVID-19 vaccine.

https://www.nytimes.com/2020/04/01/podcasts/the-daily/coronavirus-vaccine.html

Thanks & Regards,
Prashant S Akerkar

What's the take-home message of this update?

Thanks.

The news do not highlight the current development progress in % completion of COVID-19 vaccine from Curevac biotech co.

Thanks & Regards,
Prashant S Akerkar

Thanks.

Vaccines development from different Biopharma cos.

Thanks & Regards,
Prashant S Akerkar

^^ Interesting document. Where did you unearth this thing?


From my experiencing working in a lab, experiments take time to conduct - weeks, months, and years. Having a journalist probe the researchers every other day certainly won't make them work any faster.

Thank you.

https://www.indiatoday.in/science/story/coronavirus-all-you-need-to-know-about-hydroxychloroquine-and-covid-19-treatment-1664263-2020-04-07

Your views, opinion regarding
Hydroxychloroquine as a effective drug in COVID-19 treatment?

Thanks & Regards,
Prashant S Akerkar

Thanks.

https://en.wikipedia.org/wiki/Hydroxychloroquine

https://www.google.com/search?q=hydroxychloroquine+covid+19&oq=&aqs=chrome.1.35i39l4j69i177.-1j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8

https://www.google.com/search?q=hydroxychloroquine&client=ms-android-lava&prmd=nibv&sxsrf=ALeKk02Az1DMpo0ZpmCY1FMHsyN65pQswg:1586332556388&source=lnms&tbm=isch&sa=X&ved=2ahUKEwirmpOkrdjoAhWJUn0KHXr2BaQQ_AUoAnoECBQQAg&biw=360&bih=592

Thanks & Regards,
Prashant S Akerkar

Thank you.

The Hydroxychloroquine drug evaluation success will depend upon getting the latest data for COVID-19 patients cured with Hydroxychloroquine and without any other complications or side effects across the globe?

Thanks & Regards,
Prashant S Akerkar

Hydroxychloroquine works by slowing the rate at which a virus reproduces itself. This buys time for a person's immune system to build up its own defenses to take on the coronavirus.

Using a hydroxychloroquine-azithromycin cocktail appear to have helped people recover faster and avoid the most severe symptoms of COVID-19. I'm not sure how azithromycin helps - as far as I know, it is an antibiotic. I have no idea of the mechanism involved, and how it relates to viral reproduction. At the moment the extent which azithromycin could have a benefit in treating viruses and the mechanisms behind it aren’t well understood.

Thanks.

https://m.youtube.com/watch?v=keFNYV0NaxE

Thanks & Regards,
Prashant S Akerkar

Thanks.

https://m.youtube.com/watch?v=8J-06J22oj8

Thanks & Regards,
Prashant S Akerkar

Thanks.

Curevac AG replied to my email giving information that they now have created a dedicated webpage for latest updates on COVID-19 vaccine development.

https://www.curevac.com/covid-19

Thanks & Regards,
Prashant S Akerkar

Thanks for the update

Thanks.

https://www.indiatoday.in/coronavirus-outbreak/vaccine-updates/story/uk-regulator-approves-oxford-astrazeneca-coronavirus-vaccine-paves-way-for-rapid-rollout-1754466-2020-12-30

News Updates regarding
COVID-19 vaccine development.

Thanks & Regards,
Prashant S Akerkar

Not sure if the effectiveness of this one is as good as the other two by Pfizer or Moderna.

Thanks.

News updates regarding COVID-19 vaccine in India.

https://www.indiatoday.in/news-analysis/story/why-covaxin-covishield-best-option-for-india-against-covid19-pandemic-1755517-2021-01-03

Thanks & Regards,
Prashant S Akerkar

Thanks.

Currently Covishield and Covaxin COVID vaccines are administered in our country.

The third COVID vaccine from  Sputnik, Russia import is in pipeline.

https://indianexpress.com/article/india/sputnik-vaccine-covid-vaccines-coronavirus-cases-7315642/

Thanks.

Thanks & Regards,
Prashant S Akerkar

Which one are Indians mostly gravitating toward, the American or Russian vaccine?

Thanks.

https://www.businesstoday.in/coronavirus/apart-serum-bharat-biotech-5-vaccine-makers-india-hope-against-covid-19/story/439231.html

Apart from Covishield, Covaxin & Sputnik COVID vaccines, other pharma cos are being evaluated for the same to meet the requirements.

Thanks & Regards,
Prashant S Akerkar

Is Covishield an Indian-invented or Indian-manufactured vaccine?

Thanks.

https://www.seruminstitute.com/product_covishield.php

Thanks & Regards,
Prashant S Akerkar

Nevertheless, as I understand it, there is an effect