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Title: What is the method to examine translocation of some genes from Y chr to X chr? Post by: tsing_lee on Nov 6, 2021 What is the method to examine the possibility of translocation of some genes from Y chromosome to X chromosome?
Title: Re: What is the method to examine translocation of some genes from Y chr to X chr? Post by: bio_man on Nov 6, 2021 Hi tsing_lee (https://biology-forums.com/index.php?action=profile;u=1038291)
I'm assuming that the translocation of genetic material from one chromosome to another is due to breakages in chromosomes, as outlined here (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52627/pdf/pnas01070-0090.pdf). Please read the discussion thoroughly. The mapping data are consistent with the hypothesis that X/Y translocations arise by homologous recombination. The sequencing data from one translocation demonstrate this directly. |