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Title: Histone deacetylase (HDAC) inhibitors are commonly used as mood stabilizers or i Post by: barry on Jul 24, 2012 Histone deacetylase (HDAC) inhibitors are commonly used as mood stabilizers or in the treatment of neurodegenerative diseases. What effect would a HDAC inhibitor have on the target cells?
Title: Re: Histone deacetylase (HDAC) inhibitors are commonly used as mood stabilizers or i Post by: duddy on Jul 26, 2012 A histone deacetylase removes acetyl groups from the histone tails. This process results in tighter chromosome compaction and thus less transcription of the genes in that region of the chromosome. HDAC inhibitors block this enzyme, resulting in hyperacetylation of histones and an increase in gene expression in the target cells, which can increase transcription (and translation) of gene products that may be decreased in the diseased tissues.
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