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Title: How does a cholinesterase inhibitor work in a synapse? Post by: luckylimited on Mar 16, 2017 Cant find exact information.
Title: Re: How does a cholinesterase inhibitor work in a synapse? Post by: cloveb on Mar 16, 2017 Cholinesterase is an enzyme that produced in the liver, is one of many important enzymes needed for the proper functioning of the nervous systems of humans, other vertebrates, and insects.
Nerve impulses are transmitted across synapses through the release of a chemical called acetylcholine. After the stimulating signals are transferred, cholinesterase is released by the body and the acetylcholine is broken down into its acetyl and choline components and removed from the synapse, allowing other signals to pass through. Cholinesterase inhibiting chemicals, most notably organophosphate and carbamate Pesticides, do not allow cholinesterase to end the stimulating signal which causes a build up of stimulating signals in the nervous system. Because they cannot be removed, the stimulating signals continue firing in the body which results in the uncontrollable movements that are the sign of cholinesterase inhibition including rapid muscle twitching, convulsions, and others. |