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Title: TCA cycle Post by: minjai0322 on Oct 19, 2010 List two of the cofactors involved in the reaction catalyzed by pyruvate dehydrogenase. What is a cofactor of an enzyme?
Title: Re: TCA cycle Post by: bio_man on Oct 19, 2010 Pyruvate dehydrogenase (E1) performs the first two reactions within the pyruvate dehydrogenase complex (PDC): a decarboxylation of substrate 1 (pyruvate) and a reductive acetylation of substrate 2 (lipoic acid). Lipoic acid is covalently bound to dihydrolipoamide acetyltransferase (E2), which is the second catalytic component enzyme of PDC.
More information can be found here... http://rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/11-krebs.ppt (http://rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/11-krebs.ppt) |