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Title: What is the difference between a loss of function mutation and leaky mutation? Post by: Moso13 on May 3, 2017 Is a null mutation the same thing as a loss of function mutation?
Title: Re: What is the difference between a loss of function mutation and leaky mutation? Post by: bio_man on May 3, 2017 Null vs loss of function. Short answer, they are different.
Loss-of-function mutations, also called inactivating mutations, result in the gene product having less or no function (being partially or wholly inactivated). Less-severe mutations are called “leaky” mutations because some normal function still “leaks through” into the phenotype. |