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Title: Which among the buffer system of H2CO3 and HCO3- has a higher concentration in normal blood pH? Why? Post by: michele 84 on Feb 14, 2013 Normal venous blood has a pH of about 7.4. Blood pH is controlled by the buffer system of H2CO3 and HCO3-. Which would one expect to have a higher concentraion. Please explain in detail. Thanks!
Title: Which among the buffer system of H2CO3 and HCO3- has a higher concentration in normal blood pH? Why? Post by: tony960831 on Feb 14, 2013 pH = pKa + log [HCO3-] / [ H2CO3]
Ka for the equilibrium H2CO3 <----> HCO3- + H+ is 4.2 x 10^-7 pKa = 6.4 7.4 = 6.4 + log [HCO3-] / [H2CO3] If [HCO3-] = 10 [ H2CO3 ] log [ HCO3 - ] / [ H2CO3 ] = 1 7.4 = 6.4 + 1 |