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Title: what metabolite accumulates in individuals with beriberi and why? Post by: michelfelcon on Mar 6, 2013 Beriberi is a disease that results from a dietary lack of thiamine. There are 2 metabolites that accumulate in individuals with beriberi, especially after the ingestion of glucose. Which metabolites accumulate and why?
Title: what metabolite accumulates in individuals with beriberi and why? Post by: firefighterjn on Mar 6, 2013 A thiamine derivative is necessary for the decarboxylation of pyruvate in the pyruvate dehydrogenase complex. This complex is a group of enzymes and cofactors that form acetyl CoA (from pyruvic acid formed form glucose in glycolysis) that condenses with oxaloacetate to form citrate, the first component of the citric acid cycle.
As a result pyruvic acid and lactic acid accumulate. |