Biology Forums - Study Force

Using recombination frequency to map genes relative to each other is a powerful tool in genetics. A major limitation, however, is that Genetic Distance has an upper limit (i.e. one cannot establish linkage for genes that are more than 50 cM distant). Please discuss/describe this limitation. Why is there a limit? What does it mean?

Genetic frequency /recombination frequency, recombination is the one of the key evolutionary shaping the architecture of the genome, it involves the rearrangement of the genetic material it joins the perilously unassociated DNA fragments is often acomplished by the breaking and rejoining of DNA fragments.

There will be four types of recombinations one is homolougs, heterologous, site specific , transposition. Recombination frequencies can be used for the map the position of the loci on a linear linkage group ,the order of the genes and relative distance between them in a linkage group corresponds to their order and relative distance on the chromosome .

At a very small distance recombination very rarely occurs, this leads to the generation of offspring only with type parental type .

At very large distance recombination occurs very frequently ,this leads to production more recombinants and there by leading to loss of the parental genotype this act as a major limitation of the genetic frequencies .frequent cross overs occur.

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I hope this helps :sweat:

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