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Laboratory Help Upper-Year Courses Topic started by: Vickys05 on Sep 18, 2011



Title: Physioex 9.0 Exercise 1
Post by: Vickys05 on Sep 18, 2011
Activity 4; Simulating filtration

25.   Why did increasing the filtration pressure increase the filtration rate but not the concentration of solutes?


Title: Re: Physioex 9.0 Exercise 1
Post by: duddy on Sep 18, 2011
Activity 4; Simulating filtration

25.   Why did increasing the filtration pressure increase the filtration rate but not the concentration of solutes?

Here's what I think: Glomerular filtration rate increased because the net filtration pressure was increased. Net filtration pressure relies on glomerular hydrostatic pressure. This, however, doesn't mean more solute will pass through, since solute concentration is dependent on whether the solute is permeable or not. If the solute is not permeable to the membrane, than no matter what pressure applied, it won't pass through (it's likely too large).