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Title: digitalis and ultimate effect on on cytoskeletal protein Post by: faraz on Sep 5, 2010 What specific cytoskeletal protein has its function altered as the ultimate effect of digitalis?
Title: Re: digitalis and ultimate effect on on cytoskeletal protein Post by: bio_man on Sep 5, 2010 What course is this for?
I would say alpha-adducin Moreover, Digitalis also disrupts cytoskeletal functions by inhibiting alpha-tubulin polymerization into microtubules! Title: Re: digitalis and ultimate effect on on cytoskeletal protein Post by: duddy on Sep 5, 2010 Faraz:
Digitalis alkaloids: Na+/ K+-ATPase inhibitors => intracellular Na+ raises => Na+/Ca2+ exchange less efficient => Ca2+ intracellular increases => stronger contractions high intracellular Ca2+ ions can inhibit the assembly of microtubules (tubulin being the major component of cytoplasmic microtubules) and, therefore, play a role in the regulation of microtuble formation. Makes sense? |