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Title: Suppose that a couple has two daughters, Jessica and Robin. Jessica has one norm Post by: jessica90 on May 1, 2013 Suppose that a couple has two daughters, Jessica and Robin. Jessica has one normal Rb gene and one copy that has a nonsense mutation. Robin has two normal copies of Rb.
What needs to happen in order for Jessica to develop retinoblastoma? What needs to happen in order for Robin to develop retinoblastoma? Title: Re: Suppose that a couple has two daughters, Jessica and Robin. Jessica has one norm Post by: bio_man on May 1, 2013 Jessica needs to acquire a mutation in her one functional Rb gene ( Loss of heterozygosity). Robin needs two dependent mutations (one in each of functional Rb gene copies).
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