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Title: Protein cleaving Post by: chang190 on Oct 29, 2010 Under which one of the following conditions would the signal peptide of a protein be cleaved off by signal peptidase?
1.If a transmembrane protein's N-terminus is in the cytoplasm, its C-terminus in the lumen, and it crosses the membrane 3 times 2. If a transmembrane protein's N-terminus is in the lumen, its C terminus in the cytoplasm, and it crosses the membrane once 3. If a transmembrane protein's N-terminus is in the cytoplasm and the C-terminus is in the luman and it crosses the membrane once 4. If a transmembrane protein's N and C-termini are in the cytoplasm and it crosses the membrane twice 5. If a transmembrane protein has its N- and C-termini in the cytoplasm and it crosses the membrane four times Title: Re: Protein cleaving Post by: duddy on Oct 29, 2010 Ah, Hmm, this one is tough.
If N-terminal signal peptide fragments are released into the cytosol, then there must be an intramembrane cleaving protease called signal peptide peptidase that does the work. Based on this diagram: 3. If a transmembrane protein's N-terminus is in the cytoplasm and the C-terminus is in the luman and it crosses the membrane once Seems right. Check it out: http://www.signalpeptide.de/ (http://www.signalpeptide.de/) |