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Title: How is a microarray used to scan for mutations in a genome? Post by: colleen on Sep 22, 2013 How is a microarray used to scan for mutations in a genome?
Title: Re: How is a microarray used to scan for mutations in a genome? Post by: maria1995 on Sep 22, 2013 The microarray chip contains DNA sequences representing specific regions of the human genome. Patient DNA is
hybridized to the chip to detect unbalanced chromosomal abnormalities(copy number changes)thatmay not be identified byconventionalkaryotype.Genom icmicroarraycanalsobeusedtofu rther characterize cytogenetic abnormalitiesidentified by conventional cytogenetic methods. The analysisis performed using arrayed oligonucleotide probes and comparative genomic hybridization (CGH) techniques. • This technique will only detect imbalances (gain or loss of DNA) in the genome. Balanced rearrangements, such as translocations and inversions, mutations, or small genomic abnormalities between or within probes, will not be detected Title: Re: How is a microarray used to scan for mutations in a genome? Post by: walid on Sep 22, 2013 Content hidden
Title: Re: How is a microarray used to scan for mutations in a genome? Post by: colleen on Sep 23, 2013 Fantastic!!
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