Title: Calculating probabilities in pedigrees of X-linked conditions Post by: freeblue on Jan 2, 2014 I understand this chapter for the most part, but I really can't solve this one question. Sorry, I couldn't get the question all in one screenshot so I had to use two! Thanks in advance for the help!
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: padre on Jan 2, 2014 Content hidden
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: Pjjjw on Oct 9, 2014 Thanks
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: ldiaz2012 on Oct 16, 2014 Thanks for the great explanations! really helpful :D
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: padre on Oct 16, 2014 Given the feedback, I'm marking this as solved, unless someone else can come up with something.
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: vynovegil on Oct 26, 2014 A good method for calculating probabilities in pedigrees is to consider the requirements for a certain outcome.
For question 1, the following are required for IV-3 to have condition A (aa): II-5 has the genotype Aa (probability = 2/3). If II-5 has the genotype Aa (accounted for by the above probability), then he passes an a allele to III-4 (probability = 1/2). If III-4 has the genotype Aa (accounted for by the above probability), then she passes an a allele to IV-3 (probability = 1/2). II-7 has the genotype Aa (probability = 2/3). If II-7 has the genotype Aa (accounted for by the above probability), then he passes an a allele to III-5 (probability = 1/2). If III-5 has the genotype Aa (accounted for by the above probability), then he passes an a allele to IV-3 (probability = 1/2). All of these requirements are needed in sequence, so you apply the product rule (2/3 x 1/2 x 1/2 x 2/3 x 1/2 x 1/2 = 1/36). Similarly, for question 2, the following are required for IV-3 to have condition B: II-4 passes an X b chromosome to III-4 (probability = 1/2). If III-4 has the genotype X B X b (accounted for by the above probability), then she passes an X b chromosome to IV-3 (probability = 1/2). III-5 passes a Y chromosome to IV-3 (probability = 1/2). All of these requirements are needed in sequence, so you apply the product rule here, too (1/2 x 1/2 x 1/2 = 1/8). Once the individual probabilities are known, the sum and/or product rules can be used for various combinations (both conditions, either condition, etc.) Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: gw234 on Nov 6, 2014 Thank You
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: grumbelcakes on Nov 6, 2014 Thank you
Title: Calculating probabilities in pedigrees of X linked conditions Post by: PhillipePet on Jul 13, 2015 No, we dont. Or I dont. Ive read your all your posts since we started posing the question, and I can find no answer.
You may think youve answered it, but in that case, you need to link to it, so that we can figure out why your answer doesnt look like one to us. Do you understand that you cannot begin to calculate a probability until a you know what event or class of events you are calculating the probability of and b under what conditions the probability is to be calculated for? Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: padre on Aug 23, 2015 ^^ My post has the accepted answer...
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: Loloboi on Feb 11, 2016 ;D
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: shaneisbased on Sep 30, 2018 8-)
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: BennyDooney on Oct 20, 2018 Thank you!!
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: Noharmony on Dec 12, 2018 Thank you!
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: markatlor on Dec 14, 2018 Thanks!
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: lions1 on Jan 3, 2019 thank you
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: Aum Patel on Oct 31, 2019 thanks
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: Vaibhav Kumar on Nov 19, 2019 thanks! this post is great
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: 1111122222333 on Dec 11, 2019 thanks
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: Ahmad Khan on Jan 4, 2020 thanks
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: Jenna Duursma on Feb 8, 2020 Thank you!
Title: Re: Calculating probabilities in pedigrees of X-linked conditions Post by: Christina Constancio on Apr 1, 2020 Thank you for the help!
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