This week in Science, researchers led by genome sequencing pioneer Craig Venter report engineering a bacterium to have the smallest genome - and the fewest genes - of any freely living organism. Known as Syn 3.0, the new organism has a genome whittled down to the bare essentials needed to survive and reproduce, just 473 genes. However, the function of 149 of Syn 3.0's 473 genes remain unknown.

As Syn 3.0's name suggests, it’s not the first synthetic life made by Venter. In 2010, Venter's team reported that they had synthesized the sole chromosome of Mycoplasma mycoides - a bacterium with a relatively small genome - and transplanted it into a separate mycoplasma called M. capricolum, from which they had previously extracted the DNA. After s ...