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colleen colleen
wrote...
Valued Member
Posts: 17076
12 years ago
Describe a major problem in scaling up from a small batch culture in the lab to a large-scaled fermentor. Also explain how the problem is assuaged or avoided.
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Sunshine ☀ ☼

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Donated
Valued Member
12 years ago
One of the most important issues is sufficient oxygen to facilitate rapid (aerobic) growth. Aeration systems that involve a sparger to bring in sterile air and an impeller to stir and distribute the oxygen are often used to maintain high oxygenation.
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