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Home Q & A Board Biology-Related Homework Help Anatomy and Physiology
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nite_n_day nite_n_day
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11 years ago
In glomerulonephritis, the normal filtration barrier is damaged and becomes far more permeable to plasma proteins, such as albumin along with other solutes. How would that affect glomerular filtration?
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Eric Clapton
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11 years ago
Online answer: "When the glomerular basement membrane is damaged as a result of pathology, it becomes more permeable to substances which would normally not travel through this barrier. As a result, certain substances will appear in the urine as they are no longer effectively filtered out. This is particularly evident with proteins, which is why this value is often measured in a urinalysis."
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11 years ago
GFR would go up for two reasons. (1) The leakage of protein into the capsular filtrate will lower the effectiveness of BCOP and thus raise the net filtration pressure. (2) Filtration will increase also because of the increased leakiness of the glomerulus to water, ions, and other solutes. A distinct proteinuria will appear, and the loss of protein will lower BCOP, making matters worse and promoting edema formation in the peripheral tissues.
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nite_n_day Authornite_n_day
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11 years ago
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Would you know my name, if I saw you in heaven?

Eric Clapton

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