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Home Q & A Board Biology-Related Homework Help Medicine Nursing and Clinical
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Ij23 Ij23
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6 years ago
The hypothalamic-pituitary-adrenal (HPA) axis is considered the stress axis. How is the HPA axis implicated in the etiology of mood disorders?
 
  A) Increased activity of the HPA axis results in hypersecretion of adrenal glucocorticoids and corticotrophin-releasing hormone (CRH), which contributes to mood disorders.
  B) Decreased activity of the HPA axis results in hyposecretion of adrenal glucocorticoids and CRH, which contributes to mood disorders.
  C) Increased activity of the HPA axis results in depletion of adrenal glucocorticoids and CRH, which contributes to mood disorders.
  D) Decreased activity of the HPA axis results in excessive amounts of adrenal glucocorticoids and CRH, which contributes to mood disorders.
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#1
6 years ago
Ans: A
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Uncontrollable stressors lead to sustained hyperactivity of the HPA axis. The result is hypersecretion of adrenal glucocorticoids and CRH. In major depression, protracted elevation of glucocorticoid levels desensitizes the central glucocorticoid receptors and probably also those receptors located on macrophages, an important component of the immune response.
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