Mr. Singh is a 66-year-old man who is receiving chemotherapy for the treatment of lung cancer that ...

Mr. Singh is a 66-year-old man who is receiving chemotherapy for the treatment of lung cancer that has metastasized to his liver. In an effort to prevent infection, Mr. Singh has been prescribed filgrastim (Neupogen).
 
  Which of the nurse's following assessment questions most directly addresses a common adverse effect of filgrastim?
  A) Have you noticed any bleeding in your gums or cheeks?
  B) Do you feel like you're having any pain in your bones?
  C) Are you experiencing any waves of cool, clammy skin?
  D) Have you had any shortness of breath lately?