Inhibitors of enzymes can be either reversible or irreversible. In addition, most reversible ...

Inhibitors of enzymes can be either reversible or irreversible. In addition, most reversible inhibitors are either competitive or noncompetitive.

Based on what you know about enzyme inhibition, classify the following examples as irreversible, competitive, or noncompetitive enzyme inhibition.

A) competitive
B) noncompetitive
C) irreversible

1) Diisopropyl fluorophosphate binds to acetylcholinesterase and permanently inactivates the enzyme. Paralysis results.
2) A drug binds to the active site of an enzyme but disassociates and leaves the enzyme active.
3) A toxin binds to the surface of an enzyme. The enzyme then binds the substrate, but no product is produced. The toxin may disassociate and the enzyme will become active again.
4) Vitamin K is a coenzyme involved in blood clotting. An anticoagulant drug binds at the site of vitamin K bonding, blocking vitamin K binding and preventing clotting. Clotting resumes after the patient stops taking the drug.
5) Aspirin binds to prostaglandin synthetase and permanently stops its ability to produce prostaglandin.

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Inhibitors of enzymes can be either reversible or irreversible. In addition, most reversible ...

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