An 8-month pregnant woman asks the nurse, Does my baby have any antibodies to fight infection? The ...

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1. Incorrect. During the third trimester, the only immunoglobulin that crosses the placenta, IgG, provides passive acquired immunity to specific bacterial toxins. The fetus produces IgM by the end of the first trimester. IgA immunoglobulins are not produced by the baby.
2. Incorrect. By the third trimester, the fetus has IgG and IgM. Breastfeeding will supply the baby with IgA immunoglobulins.
3. Incorrect. This is not an accurate statement. By the third trimester, the fetus has IgG and IgM.
4. Correct. During the third trimester, the only immunoglobulin that crosses the placenta, IgG, provides passive acquired immunity to specific bacterial toxins. The fetus produces IgM by the end of the first trimester.

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