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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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jeremy.l32 jeremy.l32
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6 years ago
In E. coli, how does the mismatch repair system able to detect which of the two mismatched bases is correct and which is incorrect?
 
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6 years ago
Ans: Both strands of E. coli DNA are methylated by a methylase coded by the dam gene. Specifically, the A in the sequence GATC is methylated. After replication, the template strand is methylated while the newly synthesized strand is not, so the repair system can recognize the methylated strand as the correct one. Eventually, however, Dam methylase will methylate the new strand as well.
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