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kyrabunga kyrabunga
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6 years ago
Compare and contrast the two approaches to genome sequencing (whole-genome shotgun sequencing and clone-by-clone sequencing).
 
  What will be an ideal response?
Textbook 
Genetic Analysis: An Integrated Approach

Genetic Analysis: An Integrated Approach


Edition: 3rd
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wrote...
6 years ago
Both approaches seek to completely cover an organism's entire genome and both require piecing together overlapping sequences.
WGS overlaps sequences after random fragmentation and sequencing of those fragments.
CBC use sequences from already overlapping chromosomal fragments.
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