Gene regulation in prokaryotes and eukaryotes

Delta-Notch

wrote...

14 years ago

Gene regulation in prokaryotes and eukaryotes

I want to list all possible gene regulation processes that are available in prokaryotic and eukaryotic cells.

I will be glad if you help me to complete my list.

eukaryote:
- accessibility of chromatin (DNA-(de)methylation; histon (de)acetylation)
- transcription: Enhancer & tanscription factors
- RNA-processing: alternative splicing, alternative poly(a) sites
- Translation: RNAi (inhibition, degradation)
- Protein processing (modification, partial proteolysis)
- Protein degradation (proteasom)
- Transportation of the protein to the target structure

prokaryote
- Operator: activator and repressor
- attenuation (e.g. trp-operon)
- protein modification?

Question: is there also RNAi in prokaryotes?

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duddy

wrote...

Staff Member

14 years ago

Hey delta, RNAi is mainly found in eukaryotes

Gene expression in prokaryotes is influenced by an RNA-based system similar in some respects to RNAi. Here, RNA-encoding genes control mRNA abundance or translation by producing a complementary RNA that binds to an mRNA by base pairing. However these regulatory RNAs are not generally considered to be analogous to miRNAs because the dicer enzyme is not involved.

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Delta-Notch Author

wrote...

14 years ago

Ah thanks. I have never read about that in my molecular biology books.

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duddy

wrote...

Staff Member

14 years ago

Quote from: Delta-Notch (14 years ago)

Ah thanks. I have never read about that in my molecular biology books.

You're welcome Slight Smile

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- Bachelor of Science

Delta-Notch Author

wrote...

14 years ago

Now another thought crosses my mind:

The use of restriction enzymes in bacteria might be another
possibility of prokaryotic regulation of gene expression.

-> The cutting down of extrinsic linear DNA avoids it's transcription!?

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duddy

wrote...

Staff Member

14 years ago

Quote from: Delta-Notch (14 years ago)

-> The cutting down of extrinsic linear DNA avoids it's transcription!?

... that makes sense

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