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Delta-Notch Delta-Notch
wrote...
13 years ago
I want to list all possible gene regulation processes that are available in prokaryotic and eukaryotic cells.

I will be glad if you help me to complete my list.



eukaryote:
- accessibility of chromatin (DNA-(de)methylation; histon (de)acetylation)
- transcription: Enhancer & tanscription factors
- RNA-processing: alternative splicing, alternative poly(a) sites
- Translation: RNAi (inhibition, degradation)
- Protein processing (modification, partial proteolysis)
- Protein degradation (proteasom)
- Transportation of the protein to the target structure



prokaryote
- Operator: activator and repressor
- attenuation (e.g. trp-operon)
- protein modification?



Question: is there also RNAi in prokaryotes?

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Replies
wrote...
Staff Member
13 years ago
Hey delta, RNAi is mainly found in eukaryotes

Gene expression in prokaryotes is influenced by an RNA-based system similar in some respects to RNAi. Here, RNA-encoding genes control mRNA abundance or translation by producing a complementary RNA that binds to an mRNA by base pairing. However these regulatory RNAs are not generally considered to be analogous to miRNAs because the dicer enzyme is not involved.
- Master of Science in Biology
- Bachelor of Science
Delta-Notch Author
wrote...
13 years ago
Ah thanks. I have never read about that in my molecular biology books.

wrote...
Staff Member
13 years ago
Ah thanks. I have never read about that in my molecular biology books.

You're welcome Slight Smile
- Master of Science in Biology
- Bachelor of Science
Delta-Notch Author
wrote...
13 years ago
Now another thought crosses my mind:

The use of restriction enzymes in bacteria might be another
possibility of prokaryotic regulation of gene expression.

-> The cutting down of extrinsic linear DNA avoids it's transcription!?
wrote...
Staff Member
13 years ago
-> The cutting down of extrinsic linear DNA avoids it's transcription!?

... that makes sense
- Master of Science in Biology
- Bachelor of Science
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