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A nurse is teaching an 81-year-old man about the risk for potential adverse effects before he begins a course of antibiotics for an upper respiratory infection. What characteristic of older adults predisposes them to adverse drug reaction?
A)Increased excretion time due to increased bowel motility
B)Impaired distribution due to polypharmacy
C)A decrease in overall body surface area
D)A decrease in the number of receptors needed for distribution
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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Older adults are prone to adverse drug reactions because of a decrease in the number of receptors needed for drug distribution. BSA does not change appreciably with age and bowel motility slows with age. Polypharmacy is a valid concern, but this phenomenon does not primarily involve distribution.

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