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Laboratory testing of an 80-year-old patient who is well-known to the clinic nurse indicates that his liver function has been gradually decreasing over the last several years. How will this age-related physiological change influence drug metabolism?
A)The patient will metabolize drugs more quickly but derive less of a therapeutic benefit from them.
B)The liver will sequester drug molecules in the hepatocytes, and they will be released at unpredictable times.
C)Many of the patient's medications will remain in his body for a longer time.
D)The patient's kidneys will be forced to metabolize a disproportionate quantity of medications.
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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The hepatic enzymes of the liver are decreased in the older adult, altering the ability to remove metabolic by-products. It is important to understand that because older adults have a reduced metabolism, medications with a long half-life will remain in the body for a greater amount of time. The kidneys do not compensate for this loss of function. Drugs are not normally sequestered in the liver tissue.

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