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A nurse is reviewing a new patient's admission blood work, which indicates that the patient's glomerular filtration rate is 51 mL/min/1.73 m2 (low). What implication does this have for the patient's subsequent pharmacotherapy?
A)The patient may need lower-than-normal doses of some medications.
B)The patient may require a fluid challenge prior to medication administration.
C)The patient may need IV administration of a hypotonic solution to aid medication excretion.
D)The patient may need to receive medications by topical and subcutaneous routes rather than parenteral.
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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With a decreased GFR, it is necessary to reduce the dosage of the medication. IV fluid administration and alternative routes do not adequately compensate for this change in pharmacokinetics.

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