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2 months ago
An adult male patient with a diagnosis of osteomyelitis will soon begin treatment with gentamicin. Which of the following schedules is most likely to maximize efficacy and minimize nephrotoxicity?
A)Gentamicin 500 mg IV OD at 1200
B)Gentamicin 250 mg PO BID at 07:30 and 19:30
C)Gentamicin 500 mg PO TID at 08:00, 12:00, and 17:00
D)Gentamicin 125 mg IV QID at 06:00, 1200, 18:00, and 24:00
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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The ODA method uses higher doses (e.g., 4 to 7 mg/kg) to produce high initial drug concentrations, with no repeat dosing until the serum concentration is quite low (typically 24 hours later). The rationale for this dosing approach is a potential increase in efficacy with a reduced incidence of nephrotoxicity. Gentamicin is not administered orally.

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