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A patient is administered a nucleotide reverse transcriptase inhibitor in combination with a nonnucleotide reverse transcriptase inhibitor. What is the main rationale for administering these medications together?
A)They facilitate increased adherence to treatment.
B)They decrease the length of illness.
C)They have synergistic antiviral effects.
D)They prevent the development of opportunistic infections.
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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C
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Because the two types of drugs inhibit reverse transcriptase by different mechanisms, they may have synergistic antiviral effects. The use of two medications may decrease adherence because of the burden of taking two medications. The use of two medications will not decrease the length of the illness. They will not decrease all opportunistic infections.

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