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A week ago
An adult patient has questioned whether fexofenadine (Allegra) would be preferable to the first-generation H1 receptor antagonists that he has long taken in the treatment of his environmental allergies. When describing the benefits of second-generation drugs such as Allegra, the nurse should cite what advantage?
A)Lower cost
B)Decreased sedation
C)Absence of adverse effects
D)Once-weekly dosing
Source  Download
Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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Unlike the first-generation H1 receptor antagonists, the second-generation H1 receptor antagonists do not readily enter the brain from the blood. This selectivity significantly reduces the occurrence of adverse drug reactions, such as drowsiness and sedation, while still providing effective relief of allergic conditions. Adverse effects are not wholly absent, however. Duration of action is 12 to 24 hours, and these drugs are more expensive than first-generation drugs.

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