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A nurse is reviewing a newly admitted patient's medication administration record and notes that the patient takes a loop diuretic as well as a thiazide diuretic. The nurse understands what primary rationale for the concurrent use of these two drugs?
A)Increased diuretic effect
B)Reduced risk of potassium imbalances
C)Decreased blood pressure without a risk of bradycardia
D)Increased adherence to treatment
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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When an inadequate diuretic response occurs with one drug, people sometimes take two potassium-losing diuretics concurrently. The combination of a loop and a thiazide diuretic has synergistic effects because the drugs act in different segments of the renal tubule. Thus, the rationale for this particular combination is not rooted in prevention of potassium imbalances, increased adherence, or maintenance of a normal heart rate.

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