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wrote...
Valued Member
Educator
4 years ago
Thanks for clarifying

Would running out of supply lead to depression as described above?

Absolutely, yes

Cocaine withdrawal leads to depression, anxiety, agitation, paranoia and drug craving.
oemBiology Author
wrote...
4 years ago
"cocaine blocks that reuptake, especially of dopamine, allowing these powerful chemicals to float around and accumulate - making the user feel eiphoric for a time, but also paranoid and jittery. And because you have a limited supply of these neurotransmitters, and your body needs time to brew more, flooding your synapses like this eventually depletes your supply, making you feel terrible in a number of ways"

Could you please describe more on how biological processes work, once reuptake is blocked? What process would depletes the supply of these neurotransmitters continually?
If limited supply is running out, what would go to happen within neurons?

Do you have any suggestions?
Thank you very much for any suggestions (^v^)
wrote...
Valued Member
Educator
4 years ago
Could you please describe more on how biological processes work, once reuptake is blocked? What process would depletes the supply of these neurotransmitters continually? If limited supply is running out, what would go to happen within neurons?

Cocaine prevents dopamine from being recycled back into the presynaptic neuron, causing large amounts to build-up in the space between two nerve cells. This flood of dopamine in the brain’s reward circuit strongly reinforces drug-taking behaviors, because the reward circuit eventually adapts to the excess of dopamine caused by cocaine, and becomes less sensitive to it. As a result, people take stronger and more frequent doses in an attempt to feel the same high, and to obtain relief from withdrawal.
oemBiology Author
wrote...
4 years ago Edited: 4 years ago, oem7110
Let apply cocaine's logic into feeling blue during winter, if SERT vacuuming process (reuptake) is more active, preventing these powerful serotonin to float around and accumulate - what would make the user feel?

Would the frequency of impulse signals increase as biological processes work faster on feedback loops?

Do you have any suggestions?
Thank you very much for any suggestions (^v^)
wrote...
Valued Member
Educator
4 years ago
Because rather than reaching the post synaptic neuron, it gets sucked back into the pre synaptic neuron.
oemBiology Author
wrote...
4 years ago Edited: 4 years ago, oem7110
Therefore it is less impulsing signal to activate serotonin-receptors on the postsynaptic neuron.  The purpose of impulsing signal is to send messages to other organs, if there is less signals, I would like to know on how organs are being affected on performance under this situation.

Do you have any suggestions?
Thank you very much for any suggestions (^v^)
wrote...
Valued Member
Educator
4 years ago
* I'm assuming you're speaking of a nerve impulse.

  • If an action potential is initiated, the response is the same.
  • If an action potential is not initiated, there's no response at the other end.

Hope I understood you correctly
oemBiology Author
wrote...
4 years ago
Due to SERT reducing the chance of initiating action potential, message (impulsing signals) cannot transfer properly from brain to any organs for certain regular tasks. Would it cause endocrine disorders?

Do you have any suggestions?
Thank you very much for any suggestions (^v^)

wrote...
Valued Member
Educator
4 years ago
Even if SERT levels are higher than normal, serotonin production is unaffected. Its release is also unaffected. The message will still be relayed to the next neuron, but rather than activating it 100% of the time, it's activate it 80% of the time instead.

Serotonin neurons innervate almost all areas of the brain the human anatomy. For example, serotonin activates respiration and enhances the stimulatory effect of CO2 on breathing.



Fig: Serotonergic projections in the human brain, arising from the raphe nuclei. The Serotonergic projections innervate sympathetic preganglionic neurons, the sensory glomeruli in olfactory bulb, the intermediate lobe of pituitary, the epithelial cells of choroid plexus, the lateral ventricles, the motor neurons of brainstem, the spinal cord, visual cortex and all regions of cerebral cortex. Other transmitter systems make specialized contacts with serotonergic targets: the dopaminergic neurons in substantia nigra, the noradrenergic neurons in locus coeruleus, pacemaker neurons of the suprachiasmatic nucleus, specialized calbindin GABA interneurons in hippocampus,and pyramidal cortical neurons. Cell types in close proximity to the serotonin fibers include glia,endothelial cells, ependymal cells in addition to the pineal gland and subcommissural organ.

Source: https://biology-forums.com/index.php?action=downloads;sa=view;down=12831
oemBiology Author
wrote...
4 years ago Edited: 4 years ago, oem7110
rather than activating it 100% of the time, it's activate it 80% of the time instead.

I would like to know on how body feels with activating 80% of the time instead of 100%, "it seems slow down the frequency of impulsing signals", correct statement? would it be the cause of generating the feeling of depression? Thinking slowly, Response slowly ...

Do you have any suggestions?
Thank you very much for any suggestions (^v^)
wrote...
Valued Member
Educator
4 years ago
Symptoms of SAD arise. SAD is a form of depression, a list of symptoms include:

Sadness, withdrawal, feelings of hopelessness or guilt, changes in sleeping or eating habits, and frequent thoughts of suicide
oemBiology Author
wrote...
4 years ago Edited: 4 years ago, oem7110
Should SERT be discussed on this issue instead of SAD? Do SAD related to SERT under this situation?

Do you have any suggestions?
Thank you very much for any suggestions (^v^)

Post Merge: 4 years ago

I would like to know on how symptoms of SAD arise under this situation.
Do you have any suggestions?
Thank you very much for any suggestions (^v^)
wrote...
Valued Member
Educator
4 years ago
SAD and SERT are intrinsically related. We discussed this a lot earlier. Please re-read this post, specifically what's in the box.

https://biology-forums.com/index.php?topic=1925261.msg4967995#msg4967995
oemBiology Author
wrote...
4 years ago Edited: 4 years ago, oem7110
Throughout the summer, sunlight generally keeps SERT levels naturally low [2]. But as sunlight diminishes in the fall, a corresponding decrease in serotonin activity also occurs.

Do you find any related reference on how sunlight keep SERT levels low based on  biological processes?
Do you have any suggestions?
Thank you very much for any suggestions (^v^)
 
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