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oemBiology Author
wrote...
4 years ago
Osteoarthritic patients experience increased joint pain in response to a decrease in pressure, pain come from inflammation.

Do you have any suggestions?
Thank you very much for any suggestions (^v^)

"Our data demonstrate that osteoarthritic patients experience increased joint pain in response to a decrease in pressure, indicating that low atmospheric pressure conditions exacerbate joint pain in these patients."
https://www.ncbi.nlm.nih.gov/pubmed/15633634

"Arthritis is a painful inflammation and stiffness of the joints. A chronic pain disorder afflicting some 19 million adult Americans, arthritis is the leading cause of disability in the US. The most common types are osteoarthritis (OA) and rheumatoid arthritis (RA), but arthritis comprises more than 100 other inflammatory diseases and conditions, including fibromyalgia, gout, and lupus."
https://www.o2oasis.com/internationally-treated-conditions/rheumatoid-arthritis/

wrote...
Valued Member
Educator
4 years ago
Ok, thanks for providing those excerpts. Are you aware that RA and OA and different diseases? RA is an autoimmune disease, while osteoarthritis is a degenerative condition that happens as a result of physical wear and tears. Therefore, what is written here cannot be correlated with RA, so your statement (below) doesn't hold true:

Quote
Since RA often occur under Low atmospheric pressure, I would like to know on how macrophage relate to inflammation under this environment as comparing with high pressure environment.  Would macrophage be more active under Low atmospheric pressure?
oemBiology Author
wrote...
4 years ago Edited: 4 years ago, oem7110
Rewording my question: Under lower atmospheric pressure, I would like to know on why Osteoarthritic patients experience increased joint pain, but they don't feel pain under higher atmospheric pressure.

Do you have any suggestions on what cause the pain?
Thank you very much for any suggestions (^v^)

Post Merge: 4 years ago

Do you find any related materials on what cause the pain?
Thank you very much for any suggestions (^v^)
wrote...
Staff Member
4 years ago
Because decreases in barometric pressure that trigger arthritis pain. A drop in barometric pressure could cause tissues that are inflamed by arthritis to expand even more, thereby aggravating the pain. This would support claims by people that their arthritis symptoms worsen when it’s cold, rainy or damp outside.

Not all studies show an association between barometric pressure and arthritis. Some suggest that barometric pressure has little or no effect on joint symptoms in people with arthritis, but many of these studies are small and believed to be flawed, according to experts who still believe that barometric pressure plays a role in arthritis pain.


it’s hard to draw any solid conclusions about arthritis and barometric pressure and the effect one has on the other. It may depend upon the type of arthritis a person has – whether it’s osteoarthritis or rheumatoid arthritis. There’s also the possibility that mental outlook has something to do with it. Barometric pressure drops in cold, damp weather are conditions that could make a person feel “down" and, possibly, more aware of their symptoms. The other possibility is the effects of barometric pressure on arthritis symptoms vary with the individual.

oemBiology Author
wrote...
4 years ago
Do you find any related articles on how lacking of oxygen trigger inflammation?

Do you have any suggestions?
Thanks, to everyone very much for any suggestions (^v^)

wrote...
Valued Member
Educator
4 years ago
Rewording my question: Under lower atmospheric pressure, I would like to know on why Osteoarthritic patients experience increased joint pain, but they don't feel pain under higher atmospheric pressure.

As mentioned by bolbol, clinical results are conflicting due to inconsistencies. These results cannot be replicated under the same conditions all the time, so scientifically it's hard to make a conclusion. Any explanations are purely hypothetically. Also, equally important to mention is that most are cohort studies, not providing biological explanations.

Quote from: bolbol
Not all studies show an association between barometric pressure and arthritis. Some suggest that barometric pressure has little or no effect on joint symptoms in people with arthritis, but many of these studies are small and believed to be flawed, according to experts who still believe that barometric pressure plays a role in arthritis pain.

Do you find any related articles on how lacking of oxygen trigger inflammation? Do you have any suggestions? Thanks, to everyone very much for any suggestions (^v^)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930928/ This article explains the correlation between the two

Let us know what you find or if you have any follow up questions.
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