Top Posters
Since Sunday
j
22
22
i
19
a
18
z
18
m
17
D
17
16
j
16
K
16
s
16
a
16
New Topic  
wrote...
Posts: 190
Rep: 9 0
A month ago Edited: A month ago, prashantakerkar
https://en.wikipedia.org/wiki/Cancer

Do you feel Vaccines can be created for Cancer disease in future?

Cancer can affect any organ of Human Being.

Are you optimistic?

If Yes, Vaccines will be created for specific organ of the Human body or a Single vaccine ?

Example :

Cancer Vaccine for Mouth
Cancer Vaccine for Lung
Cancer Vaccine for Liver
Cancer Vaccine for Pancreas
Cancer Vaccine for Blood
Cancer Vaccine for Brain

and so on ...

Thanks & Regards,
Prashant S Akerkar
Post Merge: A month ago


Thanks.

Great personalities like Steve Jobs, Nargis Dutt, Nazia Hassan, Manohar Parrikar and many more have died due to cancer disease.

Thanks & Regards,
Prashant S Akerkar
Post Merge: A month ago


Thanks.

https://en.wikipedia.org/wiki/Gardasil
Post Merge: A month ago


https://en.wikipedia.org/wiki/Cervarix

Similar to Gardasil & Cervarix cancer vaccines, Can other vaccines be manufactured for the specific Cancer organ ailment?

Thanks & Regards,
Prashant S Akerkar


Read 614 times
21 Replies
Replies
wrote...
Educator
A month ago Edited: A month ago, bio_man
Quote
Do you feel Vaccines can be created for Cancer disease in future?

I don't think vaccines - which activate one's adaptive immune system - can stop cancer cells from spreading. Cancer cells are not foreign cells, where foreign cells typically unknown cell receptors that can trigger an immune response. Cancer cells are technically mutated human cells whose DNA is messed up.

In order for the immune system to initiate a response, it needs to "observe" foreign traits circulated in the blood or tissue. As mentioned, there are no cancer receptors. These receptor may also be present on normal cells, perhaps in different quantities and under developmental control. Take, for example the receptor encoded by the gene HER2; that receptor is just over expressed. It is also present and useful in normal cells.

Similar to Gardasil & Cervarix cancer vaccines, Can other vaccines be manufactured for the specific Cancer organ ailment?

Gardasil was designed to prevent the HPV species from infecting human cells. The reason why HPV can cause cancer is because of its pathogenicity. The viral DNA may integrate into the host genome from where the E6 and E7 genes are constitutively transcribed -- this is precisely how it may cause cancer because these genes could be inserted into genes that control the cell cycle! Please read https://www.ppdictionary.com/viruses/hpv.htm for more details.

The best way to say thank you is with a positive review:

  https://trustpilot.com/review/biology-forums.com 

Your support goes a long way!


Make a note request here
wrote...
A month ago

Thanks.

https://www.netdoctor.co.uk/medicines/cancer-drugs/

No cure once cancer reaches to the advanced III stage?

Thanks & Regards,
Prashant S Akerkar
wrote...
Educator
A month ago
There's no cure at all. Cancer is hindered by stopping cell growth, and as mentioned, since cancer cells don't have a special marker, all cells (healthy and unhealthy) need to stop replicating.

At later stages of cancers, it has spread everywhere, hence it becomes practically impossible.
The best way to say thank you is with a positive review:

  https://trustpilot.com/review/biology-forums.com 

Your support goes a long way!


Make a note request here
wrote...
A month ago

Thanks.

https://www.verywellhealth.com/celebrities-who-died-of-cancer-4020414

Famous people who died because of cancer.

Thanks & Regards,
Prashant S Akerkar
wrote...
Educator
A month ago

Sad. Frowning Face

Thanks for sharing
The best way to say thank you is with a positive review:

  https://trustpilot.com/review/biology-forums.com 

Your support goes a long way!


Make a note request here
wrote...
A month ago Edited: A month ago, prashantakerkar
Thanks.

https://en.wikipedia.org/wiki/Cancer_vaccine

https://en.wikipedia.org/wiki/Tata_Memorial_Centre

Thanks & Regards,
Prashant S Akerkar

wrote...
Educator
A month ago
Thanks. https://en.wikipedia.org/wiki/Cancer_vaccine Thanks & Regards, Prashant S Akerkar

This is not your traditional vaccine though. Take from Wikipedia:

Tne approach to cancer vaccination is to separate proteins from cancer cells and immunize patients against those proteins as antigens, in the hope of stimulating the immune system to kill the cancer cells. Research on cancer vaccines is underway for treatment of breast, lung, colon, skin, kidney, prostate and other cancers.[5]

Another approach is to generate an immune response in situ in the patient using oncolytic viruses. This approach was used in the drug talimogene laherparepvec, a version of herpes simplex virus engineered to selectively replicate in tumor tissue and to express the immune stimulatory protein GM-CSF. This enhances the anti-tumor immune response to tumor antigens released following viral lysis and provides a patient-specific vaccine.[6]

Theoretically this could work as a final resort, but it's largely unproven. Still research is being conducted, and like I mentioned earlier, cancer cells go under the radar because they express nearly identical proteins to normal cells.
The best way to say thank you is with a positive review:

  https://trustpilot.com/review/biology-forums.com 

Your support goes a long way!


Make a note request here
wrote...
A month ago Edited: A month ago, prashantakerkar

Thanks.

https://en.wikipedia.org/wiki/Oncophage - Cancer Vaccine for Kidney.

Thanks & Regards,
Prashant S Akerkar
Post Merge: A month ago

Thanks.

https://www.google.com/search?q=oncophage&prmd=mvni&source=lnms&tbm=isch&sa=X&ved=2ahUKEwj5iafV0qnjAhXTgeYKHdcUBFgQ_AUoBHoECAsQBA&biw=360&bih=592

Thanks & Regards,
Prashant S Akerkar
wrote...
Staff Member
A month ago Edited: A month ago, duddy
Thanks.https://en.wikipedia.org/wiki/Oncophage - Cancer Vaccine for Kidney.Thanks & Regards,Prashant S Akerkar

Great read.

I found an article that may interest you about this "oncophage". I know it's not a traditional vaccine, in the sense that vaccines PREVENT cancers, whereas this is a proactive approach to treatment after the fact, BUT it sounds promising

@bio_man, what are your thoughts?
Attached file
(177.53 KB)
You must login or register to gain access to this attachment.
- Master of Science in Biology
- Bachelor of Science (Biology)
- Bachelor of Education
wrote...
Educator
A month ago
Hey again everyone, this is worthy of a blog article!

Here's what I found.

When these [oncophages; HSPPC-96] are re-administered to a patient following surgery or biopsy of the tumour, the antigenic tumour peptides are expressed on the surface of potent antigen-presenting cells of the immune system, such as macrophages and dendritic cells. This stimulates a much more powerful anti-tumour immune response than that generated by expression of the same antigens by the tumour cell. Thus, Antigenics autologous HSP technology is attractive because it is highly specific for individual patients and circumvents the need for identification of specific antigens for individual cancers (i.e. it does not require definition of the antigenic epitopes on cancer cells) and it overcomes the immune tolerance associated with various tumours. Oncophage is manufactured in a 10-hour process from surgically resected autologous tumour. A minimum of 1-3g of tumour tissue is required to produce enough Oncophage for a course of treatment. The major limiting factor for producing Oncophage from a particular cancer is the ability to purify HSP from that cancer. From clinical studies to date, Antigenics has been able to produce HSP from 100, 98, 90, 71 and 30% of colorectal carcinoma, renal cell carcinoma, melanoma, gastric cancer and pancreatic cancer tumours, respectively.

> Sourced below

Very promising stuff, but why haven't they continued with the research? I'd think it has to do with its success rate. For example, on Wikipedia, it states: "A first phase I clinical trial in glioma extended median survival of the group of patients, which was diagnosed with multiple recurrencies of glioma, to over 10 months."
Source https://www.ncbi.nlm.nih.gov/pubmed/11909004
The best way to say thank you is with a positive review:

  https://trustpilot.com/review/biology-forums.com 

Your support goes a long way!


Make a note request here
wrote...
A month ago

Thank you.

Thanks for the articles on Oncophage Vaccine for
Kidney cancer.

Thanks & Regards,
Prashant S Akerkar
wrote...
Staff Member
A month ago
np 👍
- Master of Science in Biology
- Bachelor of Science (Biology)
- Bachelor of Education
wrote...
A month ago Edited: A month ago, prashantakerkar
Thanks.

https://www.ncbi.nlm.nih.gov/pubmed/11909004

Oncophage Vaccine or its variants can have a potential for Pancreatic & Colorectal Cancer cure as per the article?

Thanks & Regards,
Prashant S Akerkar
Post Merge: A month ago

Thanks.

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncophage

Thanks & Regards,
Prashant S Akerkar
Attached file
Thumbnail(s):
You must login or register to gain access to this attachment.
  New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers.
Learn More
Improve Grades
Help Others
Save Time
Accessible 24/7
  125 People Browsing
Related Images
 568
 555
 399