Explain how the dietary habits of grandparents can influence

Regulation of gene expression in response to environmental cues establishes a link between nature and nurture. Such a response may be carried over to the next generation as a so-called transgenerational response (TGR), and affect offspring phenotype. For example, epigenetic changes as a result of diet transmitted through the germline in the Agouti mouse impacted five successive generations. Evidence of TGR in humans is much more limited. One of the problems in human studies is to separate genetic, epigenetic, and cultural influences in transgenerational processes. This is particularly the case if they operate simultaneously and interact, which is very possible. That is, it is possible that eating more omega-3 fatty acids, choline, betaine, folic acid and vitamin B12, by mothers and fathers, possibly can alter chromatin state and mutations, as well as have beneficial effects leading to birth of a 'super baby' with long life and a lower risk of diabetes and metabolic syndromes.