¿Existe una manera de modificar un receptor hormonal, como el IGF-1?

Hi Angelica PB

Do you mind writing this in English? It sounds like you're asking about the relationship between IGF-1 and cancer...

Here's what IGF does at the cellular level:



Circulating IGF-1 and 2 is bound to IGF binding proteins and released at the IGF-1R, which is comprised of an alpha and beta tetrameric receptor. This leads to the activation of Ras and AKT with subsequent upregulation of genes involved in cell proliferation, survival, invasion, and angiogenesis. AKT is also an upstream regulator of mTORC1 and downstream effector of mTORC2. Both mTOR complexes play an important role in positive and negative feedback on the IGF/AKT signaling pathway.