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Chembiolife Chembiolife
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How is Newton Morton's statistical method (Lod score analysis) helpful for calculating the overall probability of genetic linkage when allelic phase is unknown?
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Genetic Analysis: An Integrated Approach


Edition: 3rd
Authors:
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oveechkinoveechkin
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Morton's method determines whether genetic linkage exists between genes for which allelic phase is unknown by comparing the likelihood of obtaining the genotypes and phenotypes observed in a pedigree if two genes are linked versus the likelihood of getting the same pedigree structure if the genes assort independently. This approach assesses the probability of genetic linkage between two genes at a time and compares the probability of genetic linkage to the probability of independent assortment of the genes.

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Brilliant
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