Top Posters
Since Sunday
18
11
Z
9
7
s
6
m
6
M
6
a
6
K
6
l
5
k
5
5
New Topic  
sxllykxm sxllykxm
wrote...
Posts: 102
Rep: 0 0
2 weeks ago
Describe what is meant by a "conformational disease" and give an example. Why do you think these diseases exhibit late age of onset?
Textbook 

Genetic Analysis: An Integrated Approach


Edition: 3rd
Authors:
Read 3 times
1 Reply
Replies
Answer verified by a subject expert
beccat99beccat99
wrote...
Posts: 74
Rep: 0 0
2 weeks ago
Sign in or Sign up in seconds to unlock everything for free
More questions for this book are available here
Diseases resulting from the death of cells due to accumulation of misfolded proteins are classified as conformational diseases. Several human protein conformational diseases are known, and they are often neurodegenerative disorders and dementias. For example, Alzheimer disease is produced by the accumulation of misfolded β-amyloid protein that leads to the destruction of certain brain cells. A familial form of Parkinson disease produced by the accumulation of misfolded α-synuclein protein also results in the destruction of certain brain cells. Similarly, Huntington disease is produced by the destruction of neurons due to the accumulation of misfolded huntington protein. Each of these diseases has a late age of onset that is due to gradual cell death caused by the presence of abnormal aggregates of misfolded protein. These diseases are neuronal because that is where the genes encoding the proteins are expressed.

This verified answer contains over 140 words.
1

Related Topics

wrote...
Posts: 102
Credits: 40

2 weeks ago
Brilliant
wrote...
Posts: 71
Credits: 30

Yesterday
I appreciate what you did here, answered it right Smiling Face with Open Mouth
wrote...
Posts: 129
Credits: 125

2 hours ago
Correct Slight Smile TY
New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers
  82 People Browsing
 302 Signed Up Today
Your Opinion
Related Images
 180
 63