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heberleber heberleber
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In order to identify genes that function together in genetic pathways researchers can perform modifier screens, looking for second site enhancers or suppressors of a mutant.  Which of the following is the most reasonable strategy for carrying out a suppressor screen in particular?

▸ analyze the DNA sequence near the mutation of interest, looking for sequences that may act as silencers

▸ isolate mutants with phenotypes similar to the original mutant phenotype and then cross the mutants to identify the affected gene(s)

▸ identify mutations that, when crossed with the original mutant, result in synthetic lethality

▸ screen for enhancer-trap strains that show gene expression differences in the original mutant.

▸ mutagenize the original mutant and look for new mutations that reduce the severity of the original mutant phenotype
Textbook 
Genetic Analysis: An Integrated Approach

Genetic Analysis: An Integrated Approach


Edition: 3rd
Authors:
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RezoVIIIRezoVIII
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heberleber Author
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2 years ago
Just got PERFECT on my quiz
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Thanks
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Thank you, thank you, thank you!
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