I think bio_man might be mistaken about the blood pooling in the legs in zero gravity,
In case of normal gravityThe human cardiovascular system is quite well adapted to the constant gravitational force of the Earth. When standing, vessels in the legs constrict to prevent blood from collecting in the lower extremities. The heart is not strong enough by itself to get the blood back up the veins in legs and back to heart. The human body relies on a second system to finish that task. This system involves small valves throughout the veins and muscle contractions from the skeletal muscles when we walk and move about. The valves close when blood starts to flow in one direction, so that blood in the veins can only flow in the direction back to the heart, which is up the legs.
When we squeeze leg muscles to walk, stand or move about, the muscles squeeze the veins and force the blood to get moving. Because of the valves, the blood can only move in one direction as it gets squeezed along. So it is a combination of blood pressure from the heart's pumping action, the valves, and muscle movement that gets the blood up the legs against gravity. If the valves malfunction, then the blood falls back down to some extent after every muscle contraction and begins to pool in the veins. This causes the veins to swell with blood, which can be painful and unsightly, and is known as varicose veins.
Thus diagram shows the effect of leg muscle contraction on blood flow valve leg muscle contractions.
Due to gravitational pooling, the greater part of blood volume in the upright human is below the level of the heart. However, when a standing person suddenly changes to the supine position, gravity no longer causes a shift in blood volume from the thoracic compartment to the legs and feet. Therefore, the blood volume in the thoracic (central venous) compartment as blood volume shift away from the legs. This increases preload on the heart, thereby increasing stroke volume, although the resulting increase in cardiac output will be tempered by a reduction in heart rate. It is also worth noting that the brain accounts only for 2% of body weight, yet it receives about 15–20% of cardiac output (CO).
In case of zero gravityIn the space environment, the usual head-to-foot blood pressure and tissue fluid gradients that exist during the upright posture on Earth are removed. The subsequent shift in fluids from the lower to the upper portions of the body triggers adaptations within the cardiovascular system to accommodate the new pressure and fluid gradients.