× Didn't find what you were looking for? Ask a question
  
  
Top Posters
Since Sunday
21
8
C
6
6
m
5
m
5
m
5
c
5
c
5
m
4
b
4
i
4
New Topic  
CarbonRobot CarbonRobot
wrote...
Posts: 156
Rep: 2 0
3 weeks ago
If the body created more blood vessels would it also create more nerves? How intertwined are these two systems? Which proceeds which? Do they often interfere with one another or are they nearly step for step?
Read 179 times
16 Replies

Related Topics

Replies
wrote...
Staff Member
3 weeks ago
They're very much intertwined.

According to this article, neurons and blood vessels share common genetic pathways to acquire their fate, grow, pattern and navigate, and how both the vascular and neural systems are linked. Some other take away points are listed below:

  • Both neural and vascular progenitors use common genetic pathways to differentiate into specialized cell subtypes, all of which are optimally equipped to perform specific functions.
  • Angiogenesis and neurogenesis (for example, the birth of new neural stem cells) are closely linked and influence one another — this review highlights the molecular signals that are involved.
  • The organization of both the vascular and nervous systems requires mechanisms that determine boundary formation and the segregation of distinct cell populations: both the vascular and neural systems use common signals.
  • Wiring of the nervous and vascular networks involves the sophisticated use of attractant and repellant signals. Remarkably, both systems often use common genetic pathways to achieve this goal.
  • Vessels and nerves often track together — the recent genetic insights into how they do so are reviewed.
  • There are many more neuro-vascular disorders than originally anticipated; a perspective on their genetic basis and possible treatment is discussed.

Wish I had access to the article. If anyone here has access to Nature articles, please share it Slight Smile
- Master of Science in Biology
- Bachelor of Science (Biology)
- Bachelor of Education
wrote...
3 weeks ago
I have read that NAD+ has shown to improve vascular health and even cause new blood vessels to grow which makes me wonder if new neurons might also grow along with them.

I might have pressure on my trigeminal nerve from possibly a blood vessel. I am hoping increasing NAD+ might help nerves and blood vessels assist one another versus get in each other's way. Brain surgery is always a bad risk.
wrote...
Educator
3 weeks ago
Here you go, boys
Attached file
(1882.26 KB)
You must login or register to gain access to this attachment.
wrote...
Staff Member
3 weeks ago
Much appreciated!!

Quote
I have read that NAD+ has shown to improve vascular health and even cause new blood vessels to grow which makes me wonder if new neurons might also grow along with them.

If that is true (and I'm not verifying), with vascular regeneration comes neurogenesis.

I might have pressure on my trigeminal nerve from possibly a blood vessel.

Sounds serious man, has this been diagnosed by a medical professional?
Source https://arizonapain.com/wp-content/uploads/2021/08/trigeminal-nerve.png
Attached file
Thumbnail(s):
You must login or register to gain access to this attachment.
- Master of Science in Biology
- Bachelor of Science (Biology)
- Bachelor of Education
wrote...
3 weeks ago
No diagnosis yet. Just a vague inference in my MRI report. Neurologist didn't seem concerned but suggested I talk with a surgical specialist if I want to for more information. Probably not indicated for surgery though. I hear this type of thing can be really incapacitating at its worst. I'm not too worried, but I love to nip things in the bud when a problem is relatively slight.
wrote...
Staff Member
3 weeks ago Edited: 3 weeks ago, duddy
There's no harm in using supplements to your health. People think that everything must be "FDA-approved" to work, but that's far from true. I learned of one guy who had chronic hepatitis B that took milk thistle (Silybum marianum) from the moment he learned of his condition - milk thistle is an ancient herb known to increase liver function. Literally the virus never progressed to liver disease or cancer; he lives by it to this day. So if there's a supplement that claims to aid in NAD+ generation, continue taking it
- Master of Science in Biology
- Bachelor of Science (Biology)
- Bachelor of Education
wrote...
3 weeks ago
Well so far NAD+ precursors have only shown in humans to increase NAD+ in the liver so they are still testing those supplements. As for milk thistle I'm allergic. I think Hep B usually self resolves, and if it doesn't they have antivirals.
wrote...
Educator
3 weeks ago
How is NAD+ taken, anyway? If orally, isn't it catabolized by the digestive system before it reaches its target?

I think Hep B usually self resolves, and if it doesn't they have antivirals.

Hepatitis is a leading cause of death worldwide. The last I checked, it takes more lives than HIV. Chronic hepatitis means that it is there to stay, compared to acute. Antivirals decrease the viral load, but doesn't eliminate the virus.
wrote...
Staff Member
3 weeks ago
How is NAD+ taken, anyway? If orally, isn't it catabolized by the digestive system before it reaches its target?

They are NAD precursors. For example, as pointed out here, nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits mediated via elevated NAD+ content in the body. It's well documented, actually:

Oral supplementation with NR has been shown to increase NAD+ levels in multiple tissues, along with increased SIRT activity [10,11], improved mitochondrial function [37], and regenerative potential of stem cells [38]
- Master of Science in Biology
- Bachelor of Science (Biology)
- Bachelor of Education
wrote...
3 weeks ago Edited: 3 weeks ago, CarbonRobot
Well HIV meds can keep its virus load to undetectable so nobody needs to die of HIV anymore. As for Hepatitis there are more types than letters of the alphabet. The first 5 I think are the most treated ones. Hep C is curable in most cases now. According to Google search B is very treatable too.
Post Merge: 3 weeks ago

Dr. David Sinclair says NMN is a superior precursor for creating NAD+ in the cells. In mice models anyway most of their cells create NAD+ readily. Humans have been for fickle. They are creating new boosters that contain NMN and something else to better the absorption. That is still in human trials.
wrote...
Educator
3 weeks ago
I might have pressure on my trigeminal nerve from possibly a blood vessel. I am hoping increasing NAD+ might help nerves and blood vessels assist one another versus get in each other's way. Brain surgery is always a bad risk.

So the MRI was able to identify this particular area, and you're making the assumption it is the trigeminal nerve. Do you experience trouble talking or chewing, what about facial numbness or pain? These are symptoms of trigeminal nerve injury.
wrote...
3 weeks ago Edited: 3 weeks ago, CarbonRobot
I might have pressure on my trigeminal nerve from possibly a blood vessel. I am hoping increasing NAD+ might help nerves and blood vessels assist one another versus get in each other's way. Brain surgery is always a bad risk.
So the MRI was able to identify this particular area, and you're making the assumption it is the trigeminal nerve. Do you experience trouble talking or chewing, what about facial numbness or pain? These are symptoms of trigeminal nerve injury.

I don't have most of the physical symptoms but dull feeling around one eye and sharp pains around temple or near ear. The report said there might be some contact, but nothing so major that the myelin shealth is rubbed off. Nurse practitioner wasn't concerned but ordered MRA to accompany the MRI for good measures.
Post Merge: 3 weeks ago

How do I increase post credits again? Replying to other posts hasn't done anything lately.
wrote...
Educator
3 weeks ago
How do I increase post credits again? Replying to other posts hasn't done anything lately.

Currently, it is configured like this. I altered it this morning.


  New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers
  104 People Browsing
 266 Signed Up Today
Related Images
 4286
 437
 2418