I don t know exactely. I imagine opening and destroying the cytoplasm.

For cumulative effect of ROS caused by age.
But it depends. A young person like a smoker could have an higher ros than an aged one, for example.



It's not related.It was just an analogy that demonstrate cause and effect difference.
Cells could be destroyed detecting dna fragmentation, but dna fragmentation could be there per se, not just in the process of detecting it.

Otherwise the statement of admitting x cause dna fragmentstion should be unspeakable.


Then really I have no idea of the process to detect it I admit.
You are an educator in the forum I see..then educate me please

Beyond what I've said here is speculation, to be honest. My thoughts are if sperm antibodies do exist, the antibodies lead to an immune response that renders it incapable of fertilizing an egg. I am not concerned what actually happens after that, but common sense dictates that it doesn't have to do with fragmenting the DNA, but collectively rendering the cell dead, leading to fragmented DNA.

That ASA totally destroy sperm cells seem to be an assumption of your.
Anyway even if it happen, sperm cells attacked from ASA just die it doesn't imply that all sperm cells are attacked.
ASA drive just to partial infertility, that means not all sperm cells are attacked or those attacked are not destroyed.

If there are some sperm cells not attacked anyway every immune response cause phlogosis and then it causes ROS and this causes dna fragmentation of sperm cells remained alive.

Do you agree that phlogosis is the key?

Not sure how that relates to this discussion. Mind elaborating on this notion of phlogosis? Before this thread, I had never heard of this word.

hi
phlogosis means inflammation, this causes ros.

You mean ROS causes inflammation, right? Inflammation is part of the immune response. It depends both on the physical actions of white blood cells and the chemicals that they produce: antibodies, cytokines, and the like (which includes ROS). It is not the inflammation causing infertility, but the antibodies themselves.

ROS cause infiammation

but infiammation cause ROS too


immune response cause infiammation and infiammation cause ROS

ROS cause dna fragmentation to sperm which is different from infertility. It could cause a newborn with malformations.

That I didn't know.

I think so.

When there's inflammation caused from immune response or not, there are always cells that go in necrosis and there are debris that should be cleaned from macrophages.

Macrophages release H2O2 and then singlet oxigen which cause ROS and damages of cells and then dna fragmentation.

Do you agree?

From what I've studies, from my experience, this isn't true

Explain me better.Because I have doubts about this. What you find not true in my statement?

From what I know, ROS act as both a signaling molecule and a mediator of inflammation. But, I can see how it can be linked to a positive feedback mechanism, where ROS leads to inflammation, and inflammation leads back to more ROS. Inflammation causes immune cells to secrete various biomolecules, such as cytokines and chemokines in order to recruit various other immune cells to the site of infection, leading to more ROS. Nevertheless, you'd probably only see something like this in chronic cases.

Thanks.

But inflammation is not caused only by a prior ROS. If someone punch your eye it drives to inflammation.No?

I put these statments.Just tell me if they are true or not.

Immune response always causes ROS.

ROS always causes dna fragmentation.