× Didn't find what you were looking for? Ask a question
Top Posters
Since Sunday
g
3
3
2
J
2
p
2
m
2
h
2
s
2
r
2
d
2
l
2
a
2
Home Q & A Board Biology-Related Homework Help Cell Biology
New Topic  
CarbonRobot CarbonRobot
wrote...
Posts: 393
Rep: 8 0
A year ago
Are there consumer senolytics that are FDA approved? I am worried age research is moving too slow.
Read 254 times
5 Replies

Related Topics

Replies
wrote...
#1
Educator
A year ago
Dasatinib is an FDA-approved tyrosine kinase inhibitor
CarbonRobot Author
wrote...
#2
A year ago
Quote from: bio_man (A year ago)
Dasatinib is an FDA-approved tyrosine kinase inhibitor

Does it need to be combined with Quercetin to be that affective? And it isn't approved for the purpose of killing senescent cells?

What is a tyrosine kinase inhibitor? Prevent creation of dopamine?
wrote...
#3
Educator
A year ago
Quote
Does it need to be combined with Quercetin to be that affective?

I believe so, yes (source provided below)

As per Wikipedia:

A tyrosine kinase inhibitor is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades.

The important part:

TKIs operate by four different mechanisms: they can compete with adenosine triphosphate (ATP), the phosphorylating entity, the substrate or both or can act in an allosteric fashion, namely bind to a site outside the active site, affecting its activity by a conformational change. Recently TKIs have been shown to deprive tyrosine kinases of access to the Cdc37-Hsp90 molecular chaperone system on which they depend for their cellular stability, leading to their ubiquitylation and degradation. Signal transduction therapy can also be used for non-cancer proliferative diseases and for inflammatory conditions. An example is nintedanib for the treatment of idiopathic pulmonary fibrosis.
Source  > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796530/
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248649/
> https://en.wikipedia.org/wiki/Tyrosine_kinase_inhibitor
CarbonRobot Author
wrote...
#4
A year ago
I know that drug and Quercetin are shown effective at killing senescent cells, but are they FDA approved for that purpose? I don't know what medical purpose they would classify killing senescent cells as since they don't consider aging a disease and America isn't known for its preventative medicine. Are senolytics past clinical trials and in medical use yet?
wrote...
#5
Educator
A year ago
Quote from: CarbonRobot (A year ago)
I know that drug and Quercetin are shown effective at killing senescent cells, but are they FDA approved for that purpose?

The FDA did not approve them for that purpose, but researchers have used tested dasatinib as senolytic, in addition to quercetin (a flavonoid present in many fruits and vegetables), navitoclax, A1331852 and A1155463 (Bcl-2 pro-survival family inhibitors) and fistein (a flavonoid).

Quote
Are senolytics past clinical trials and in medical use yet?

They are not in medical use, only research purposes.

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach.
Source  https://pubmed.ncbi.nlm.nih.gov/32686219/
New Topic      
Quick Reply
Explore
Post your homework questions and get free online help from our incredible volunteers
  1136 People Browsing
 115 Signed Up Today
Start New Topic Take the Tour CoursesNew Study Tools Topics Trending Browse by Textbook
Live Chat
Related Images
  
 182
  
 249
  
 278
Your Opinion
Which industry do you think artificial intelligence (AI) will impact the most?
Votes: 352
Previous poll results: What's your favorite math subject?