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Introduction of a nonsense mutation in a eukaryotic protein coding gene often leads to:

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Introduction of a nonsense mutation in a eukaryotic protein coding gene often leads to:

▸ export of the mRNA from the cytoplasm.

▸ decreased ribosome binding in the cytoplasm to the mRNA due to its shorter size.

▸ increased degradation of the mRNA in the nucleus.

▸ increased degradation of the mRNA in the cytoplasm.

▸ retention of the mRNA in the nucleus so it is not translated.

Textbook

Lewin's GENES XII

Edition: 12^th

Authors: Krebs, Goldstein, Kilpatrick

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